33796-86-0

Basic information

• Product Name: Octanoic acid, 3-hydroxy-, (3S)-
• Synonyms: (+/-)-3-hydroxy-octanoic acid;(+/-)-3-Hydroxy-octansaeure;(+/-)-β-hydroxyoctanoic acid;3-hydroxy-octanoic acid;3-Hydroxy-caprylsaeure;3-Hydroxy-octansaeure
• CAS NO: 33796-86-0
• Molecular Formula: C8H16O3
• Molecular Weight: 160.213
• Mol File: 33796-86-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Octanoic acid, 3-hydroxy-, (3S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Octanoic acid, 3-hydroxy-, (3S)-(33796-86-0)
• EPA Substance Registry System: Octanoic acid, 3-hydroxy-, (3S)-(33796-86-0)

Safety Data

• Hazardous Substances Data: 33796-86-0(Hazardous Substances Data)

Upstream product

• 142-61-0 Hexanoyl chloride 
• 7367-90-0 ethyl β-hydroxyoctanoate 
• 66-25-1 hexanal 
• 105-36-2 ethyl bromoacetate 
• 22348-95-4 methyl 3-oxooctanoate 
• 5163-67-7 (E)-oct-3-enoic acid 

Downstream Products

• 66997-64-6 (S)-methyl 3-hydroxyoctanoate 
• 126442-53-3 (S)-3-hydroxyoctanoic acid benzyl ester 
• 7367-87-5 3-hydroxyoctanoic acid methyl ester 
• 541-50-4 2-acetoacetic acid 
• 192883-14-0 N-(3-hydroxyoctanoyl)-L-homoserine lactone 

Relevant articles and documents

Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity

A new cyclic lipopeptide, phototemtide A (1), was isolated from Escherichia coli expressing the biosynthetic gene cluster pttABC from Photorhabdus temperata Meg1. The structure of 1 was elucidated by HR-ESI-MS and NMR experiments. The absolute configurations of amino acids and 3-hydroxyoctanoic acid in 1 were determined by using the advanced Marfey's method and comparison after total synthesis of 1, respectively. Additionally, three new minor derivatives, phototemtides B–D (2–4), were identified by detailed HPLC–MS analysis. Phototemtide A (1) showed weak antiprotozoal activity against Plasmodium falciparum, with an IC50 value of 9.8 μm. The biosynthesis of phototemtides A–D (1–4) was also proposed.

Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase

Streptomyces coelicolor produces fatty acids for both primary metabolism and for biosynthesis of the secondary metabolite undecylprodiginine. The first and last reductive steps during the chain elongation cycle of fatty acid biosynthesis are catalyzed by FabG and FabI. The S. coelicolor genome sequence has one fabI gene (SCO1814) and three likely fabG genes (SCO1815, SCO1345, and SCO1846). We report the expression, purification, and characterization of the corresponding gene products. Kinetic analyses revealed that all three FabGs and FabI are capable of utilizing both straight and branched-chain β-ketoacyl-NAC and enoyl-NAC substrates, respectively. Furthermore, only SCO1345 differentiates between ACPs from both biosynthetic pathways. The data presented provide the first experimental evidence that SCO1815, SCO1346, and SCO1814 have the catalytic capability to process intermediates in both fatty acid and undecylprodiginine biosynthesis.

Graphiumins, new thiodiketopiperazines from the marine-derived fungus Graphium sp. OPMF00224

Eight new thiodiketopiperazines, designated as graphiumins A to H (1-8), were isolated along with bisdethiobis(methylthio)-deacetylaranotin (9) and bisdethiobis(methylthio)-deacetylapoaranotin (10) from the culture broth of the marine-derived fungus Graph