338990-31-1Relevant articles and documents
Prodrugs of baloxvir and derivatives thereof and preparation method and application of prodrugs
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Paragraph 0047-0050, (2021/05/05)
The present invention provides a compound having a structure represented by formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof, where X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, (R9) m in the formula (I) are defined as in the description and claims of the present invention. The compound is a prodrug of baloxavir and a derivative thereof, and the bioavailability of the compound is greatly improved compared with the bioavailability of the existing baloxavir marboxil. The compound is better than Baloxavir marboxil in the aspects of reducing the dosage, reducing the side effect of the medicine and improving the medicine effect, and can be used as a medicine for treating and/or preventing influenza virus infectious diseases.
Preparation method of liconazole sulfate and intermediate thereof (by machine translation)
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, (2019/12/25)
The preparation method disclosed by the invention has, the advantages that the preparation process efficiency of the idazooconazole sulfate and the. intermediate thereof is higher by no need C2 for column A4 chromatography and purification . and the method disclosed by, the invention only needs. to be subjected to deprotecting A4 and ion exchange by simple purification. (by machine translation)
N-substituted carbamoyloxyalkyl-azolium derivatives
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Page/Page column 21-22; 36, (2010/02/09)
N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases.