339177-03-6Relevant articles and documents
Cascade intramolecular Prins/Friedel–Crafts cyclization for the synthesis of 4-aryltetralin-2-ols and 5-aryltetrahydro-5H-benzo[7]annulen-7-ols
Meng, Shuyu,Wang, Quanrui,Zheng, Jie
supporting information, p. 1481 - 1489 (2021/07/02)
The treatment of 2-(2-vinylphenyl)acetaldehydes or 3-(2-vinylphenyl)propanals with BF3·Et2O results in an intramolecular Prins reaction affording intermediary benzyl carbenium ions, which are then trapped by a variety of electron-ric
Macrocyclic Modulators of the Ghrelin Receptor
-
, (2018/05/03)
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
Silicon- and sulfur-mediated synthesis of benzoannulated cyclooctanols
Genrich, Florian,Schaumann, Ernst
scheme or table, p. 6187 - 6190 (2010/01/03)
The reaction of a silyl-substituted thioacetal with ortho-difunctionalized benzenes as biselectrophiles allows access to multifunctional cyclooctanols.