33984-97-3

Basic information

• Product Name: cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile
• CAS NO: 33984-97-3
• Molecular Weight: 179.606
• Mol File: 33984-97-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile(33984-97-3)
• EPA Substance Registry System: cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile(33984-97-3)

Safety Data

• Hazardous Substances Data: 33984-97-3(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 107-14-2 chloroacetonitrile 
• 33984-97-3 2,3-epoxy-3-(4-chlorophenyl)propanenitrile 
• 28446-72-2 (2E)-3-(4-chlorophenyl)acrylonitrile 

Downstream Products

• 33984-97-3 cis-2,3-epoxy-3-(4-chlorophenyl)propanenitrile 
• 556053-62-4 2R,3S-(-)-3-(4-chlorophenyl)glycidamide 
• 62236-80-0 3-(4-chlorophenyl)-1H-indole 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 71512-20-4 2-(4-chlorophenyl)-N-phenylacetamide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 858788-75-7 2-(4-chlorophenyl)-5-methyl-1H-indole 
• 343965-61-7 5-(4-Chloro-phenyl)-2,2-dimethyl-[1,3]dioxolane-4-carbonitrile 
• 56791-34-5 Methyl trans-3-(4-chlorophenyl)oxirane-2-carboxylate 
• 56791-34-5 methyl cis-3-(4-chlorophenyl)glycidate 

Relevant articles and documents

BF3·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution of oxiranecarbonitriles

Tandem Meinwald rearrangement and nucleophilic substitution of oxiranenitriles was realized. Arylacetic acid derivatives were readily synthesized from 3-aryloxirane-2-carbonitriles with amines, alcohols, or water in the presence of boron trifluoride under microwave irradiation, and the designed synthetic strategy includes introducing a cyano leaving group into arylepoxides and capturing the in situ generated toxic cyanide with boron trifluoride, making the reaction efficient, safe, and environmentally benign. The reaction occurs through an acid-promoted Meinwald rearrangement, producing arylacetyl cyanides, followed by an addition-elimination process with nitrogen or oxygen-containing nucleophilic amines, alcohols or water. The current method provides a new application of the tandem Meinwald rearrangement.

Metal-free and regiospecific synthesis of 3-arylindoles

A convenient, metal-free, and organic acid-base promoted synthetic method to prepare 3-arylindoles from 3-aryloxirane-2-carbonitriles and arylhydrazine hydrochlorides has been developed. In the reaction, the organic acid catalyzes a tandem nucleophilic ri

ALPHA-HYDROXY-BETA-AZIDO-TETRAZOLES

Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and their use for synthesizing new compounds, e.g. in “click” chemistry.