34127-13-4

Basic information

• Product Name: 4(1H)-Quinazolinone, 5,6,7,8-tetrahydro-2-phenyl-
• CAS NO: 34127-13-4
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Mol File: 34127-13-4.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinone, 5,6,7,8-tetrahydro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone, 5,6,7,8-tetrahydro-2-phenyl-(34127-13-4)
• EPA Substance Registry System: 4(1H)-Quinazolinone, 5,6,7,8-tetrahydro-2-phenyl-(34127-13-4)

Safety Data

• Hazardous Substances Data: 34127-13-4(Hazardous Substances Data)

Upstream product

• 2981-10-4 1-(cyclohex-1-en-1-yl)piperidine 
• 4461-33-0 benzoyl isocyanate 
• 22945-27-3 cyclohexanone-2-carboxamide 
• 908009-77-8 2-phenyl-6-(phenylsulfonyl)-5,6,7,8-tetrahydro-3H-quinazolin-4-one 
• 908009-84-7 2-phenyl-7,8-dihydro-3H-quinazolin-4-one 
• 62582-90-5 2-Phenyl-5,6-tetramethylen-1,2-dihydropyrimidin-4(3H)-on 
• 105687-40-9 2-(3'-cyclohexenyl)-1,2,5,6,7,8-hexahydroquinazolin-4(3H)-one 
• 1670-14-0 benzamidine monohydrochloride 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 618-39-3 benzamidin 
• 552857-10-0 2-bromo-N-phenyl-1-cyclohexene-1-carboxamide 
• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 

Downstream Products

• 1436866-28-2 ethyl 2-[4-[(2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl)amino]phenyl]acetate 
• 1436866-29-3 2-[4-[(2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl)amino]phenyl]acetic acid 
• 1436866-27-1 (2-phenyl-5,6,7,8-tetrahydroquinazolin-4-yl) trifluoromethanesulfonate 

Relevant articles and documents

Microwave-assisted copper powder-catalyzed coupling and cyclization of β-bromo-α,β-unsaturated amides with amidine hydrochlorides leading to pyrimidinones

β-Bromo-α,β-unsaturated amides are coupled and cyclized with amidine hydrochlorides using microwave irradiation in the presence of a catalytic amount of copper powder and a base to give the corresponding pyrimidinones in good yields.

Fe3O4 nanoparticle-supported copper(I): Magnetically recoverable and reusable catalyst for the synthesis of quinazolinones and bicyclic pyrimidinones

A highly efficient, easily recoverable and reusable Fe3O 4 magnetic nanoparticle-supported Cu(I) catalyst has been developed for the synthesis of quinazolinones and bicyclic pyrimidinones. In the presence of supported Cu(I) catalyst (10 mol%), amidines reacted with substituted 2-halobenzoic acids and 2-bromocycloalk-1-enecarboxylic acids to generate the corresponding N-heterocycle products in good to excellent yields at room temperature in DMF. In addition, the supported Cu(I) catalyst could be recovered at least 10 times without significant loss of its catalytic activity. Copyright

Access to variously substituted 5,6,7,8-tetrahydro-3H-quinazolin-4-ones via Diels-Alder adducts of phenyl vinyl sulfone to cyclobutene-annelated pyrimidinones

Under basic conditions (Et3N, dioxane), the aromatic amidines 4 and also S-methylisothiourea 4g cleanly undergo Michael addition to methyl 2-chloro-2-cyclopropylideneacetate (5), followed by intramolecular nucleophilic substitution, cyclopropyl