3424-98-4 Usage
Description
2'-Deoxy-L-thymidine, also known as Telbivudine, is a synthetic thymidine nucleoside analog that is the L-enantiomer of thymine. It is a white solid and is used as a specific inhibitor of hepatitis B virus (HBV) replication, functioning as an antiviral agent. Telbivudine is efficiently phosphorylated by cellular kinases to the active triphosphate derivative, which inhibits HBV DNA polymerase by competing with the natural substrate, thymidine-5'-triphosphate.
Uses
Used in Antiviral Applications:
2'-Deoxy-L-thymidine is used as a nucleoside analog for the inhibition of HBV replication. It is particularly effective as an antiviral agent against hepatitis B virus, helping to control the viral load and prevent the progression of the disease.
Used in Hepatitis B Treatment:
In the pharmaceutical industry, 2'-Deoxy-L-thymidine is used as an active ingredient in the drug Telbivudine (brand name Novirio), which is prescribed for the once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It has been shown to be more effective than lamivudine or adefovir and less likely to cause resistance, making it a preferred choice for treating HBV infections.
Used in Research and Development:
2'-Deoxy-L-thymidine is also utilized in the research and development of new antiviral drugs and therapies. Its unique properties as a nucleoside analog and inhibitor of HBV replication make it a valuable compound for studying the mechanisms of viral replication and the development of novel treatments for viral infections.
Originator
Idenix (US)
Check Digit Verification of cas no
The CAS Registry Mumber 3424-98-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,2 and 4 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 3424-98:
(6*3)+(5*4)+(4*2)+(3*4)+(2*9)+(1*8)=84
84 % 10 = 4
So 3424-98-4 is a valid CAS Registry Number.
3424-98-4Relevant articles and documents
Meteorite-catalyzed intermoleculartrans-glycosylation produces nucleosides under proton beam irradiation
Bizzarri, Bruno Mattia,Fanelli, Angelica,Kapralov, Michail,Krasavin, Eugene,Saladino, Raffaele
, p. 19258 - 19264 (2021/06/03)
Di-glycosylated adenines act as glycosyl donors in the intermoleculartrans-glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction
Method for preparing high-purity telbivudine compound
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Paragraph 0046; 0047, (2017/01/02)
The invention belongs to the technical field of medicine and provides a method for preparing a high-purity telbivudine compound. The method includes the steps that an LTD-4 compound serves as the raw material and reacts with thymine subjected to silicification protection, and an intermediate, namely an LTD-5 compound, can be obtained; then, through deprotection reaction, the telbivudine compound is obtained after post-processing, wherein MeONa serves as an alkaline reagent of the deprotection reaction, and strong-acidity resin serves as a dealkalization reagent. The method simplifies the production process, the yield of each step is high, and a target product high in purity and yield is obtained. Please see the structural formula in the description.
METHODS FOR THE TREATMENT OF HEPATITIS B AND HEPATITIS D VIRUS INFECTIONS
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, (2016/02/26)
It is disclosed a method for treating hepatitis B virus infection or hepatitis B virus/hepatits delta virus co-infection, the method comprising administering to a subject in need of such treatment a first pharmaceutically acceptable agent that comprises at least one phosphorothioated nucleic acid polymer and a second pharmaceutically acceptable agent that comprises at least one nucleoside/nucleotide analog HBV polymerase inhibitor.
