342417-06-5

Basic information

• Product Name: 3-Pyridinecarboxamide, 4-(2-methylphenyl)-6-(4-morpholinyl)-
• CAS NO: 342417-06-5
• Molecular Formula: C17H19N3O2
• Molecular Weight: 297.357
• Mol File: 342417-06-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, 4-(2-methylphenyl)-6-(4-morpholinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, 4-(2-methylphenyl)-6-(4-morpholinyl)-(342417-06-5)
• EPA Substance Registry System: 3-Pyridinecarboxamide, 4-(2-methylphenyl)-6-(4-morpholinyl)-(342417-06-5)

Safety Data

• Hazardous Substances Data: 342417-06-5(Hazardous Substances Data)

Upstream product

• 70625-63-7 methyl 2-cyano-3-(2-methylphenyl)-2-propenoate 
• 529-20-4 2-methylphenyl aldehyde 
• 873443-68-6 2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine 
• 873443-66-4 3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine 
• 224817-12-3 6-chloronicotinic acid benzylamide 
• 115309-58-5 N-tert-butyl-6-chloro-nicotinamide 
• 342417-03-2 N-benzyl-6-chloro-4-(o-tolyl)nicotinamide 
• 342416-86-8 N-benzyl-6-(morpholin-4-yl)-4-(o-tolyl)nicotinamide 
• 342417-04-3 N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide 
• 881743-66-4 N-tert-butyl-6-(morpholin-4-yl)-nicotinamide 

Downstream Products

• 290297-36-8 N-methyl-N-[6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]amine 
• 290296-68-3 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide 
• 342417-07-6 [6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester 

Relevant articles and documents

Process for preparation of pyridine derivatives of NK-1 receptor antagonist

The present invention provides a process for preparing a pyridine compound of the formula: wherein R1, R2, R3 and a are those defined herein.

Efficient synthesis of novel NK1 receptor antagonists: Selective 1,4-addition of Grignard reagents to 6-chloronicotinic acid derivatives

A new efficient synthesis of two novel classes of NK1 receptor antagonists, among them befetupitant and netupitant, starting from 6-chloronicotinic acid is described. The introduction of the o-tolyl substituent at C(4) of the pyridine ring was achieved by a one-pot selective 1,4-Grignard addition/oxidation sequence to 6-chloronicotinic acid or a derivative of it. The scope of this addition/oxidation sequence was examined. It was also shown that the carboxylic function can be converted to a methyl amino group by a Hofmann rearrangement followed by reduction. Furthermore, a new high-yielding synthesis of 2-(3,5-bistrifluoromethylphenyl)-2-methyl propionic acid based on the carbonylation of the tertiary alcohol obtained by Grignard addition of 3,5-bis(trifluoromethyl)bromobenzene to acetone was established.