873443-66-4

Basic information

• Product Name: 2,6-dichloro-4-(o-tolyl)nicotinonitrile
• Synonyms: 2,6-dichloro-4-(o-tolyl)nicotinonitrile;3-PYRIDINECARBONITRILE, 2,6-DICHLORO-4-(2-METHYLPHENYL)-
• CAS NO: 873443-66-4
• Molecular Formula: C₁₃H₈Cl₂N₂
• Molecular Weight: 263.12202
• Mol File: 873443-66-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,6-dichloro-4-(o-tolyl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-4-(o-tolyl)nicotinonitrile(873443-66-4)
• EPA Substance Registry System: 2,6-dichloro-4-(o-tolyl)nicotinonitrile(873443-66-4)

Safety Data

• Hazardous Substances Data: 873443-66-4(Hazardous Substances Data)

Usage

Description

2,6-dichloro-4-(o-tolyl)nicotinonitrile is a chemical compound with the molecular formula C14H8Cl2N2. It is a white to light tan powder that is primarily used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. 2,6-dichloro-4-(o-tolyl)nicotinonitrile is known for its potent activity against a range of biological targets and its versatile structure, which allows for modifications to enhance its biological activity and selectivity.

Uses

Used in Pharmaceutical Industry:
2,6-dichloro-4-(o-tolyl)nicotinonitrile is used as an intermediate for the synthesis of various pharmaceuticals. Its potent activity against a range of biological targets makes it a valuable building block for the development of new drugs.
Used in Agrochemical Industry:
2,6-dichloro-4-(o-tolyl)nicotinonitrile is also used as an intermediate for the synthesis of agrochemicals. Its versatile structure allows for modifications that can enhance its biological activity and selectivity, making it a useful component in the development of new agrochemicals.
Safety Precautions:
It is important to handle 2,6-dichloro-4-(o-tolyl)nicotinonitrile with care and use appropriate safety measures due to its potential hazards when in contact with skin, eyes, and inhalation.

Upstream product

• 70625-63-7 methyl 2-cyano-3-(2-methylphenyl)-2-propenoate 
• 529-20-4 2-methylphenyl aldehyde 
• 873443-64-2 1',2',3',4'-tetrahydro-5'-cyano-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium, zwitter ion 

Downstream Products

• 290296-68-3 2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide 
• 342417-06-5 4-(2-methylphenyl)-6-(4-morpholinyl)-3-pyridinecarboxamide 
• 342417-01-0 4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide 
• 342417-02-1 [6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester 
• 290297-25-5 methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine 
• 290297-26-6 netupitant 
• 342417-07-6 [6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]carbamic acid methyl ester 
• 290297-36-8 N-methyl-N-[6-(morpholin-4-yl)-4-(o-tolyl)pyridin-3-yl]amine 
• 873443-68-6 2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-morpholinyl)pyridine 

Relevant articles and documents

Research and development of an efficient process for the construction of the 2,4,5-substituted pyridines of NK-1 receptor antagonists

Roche has identified a 2,4,5-trisubstituted pyridine template for a new class of potent NK1 receptor antagonists. Previous strategies for construction of the pyridine core of these NK-1 receptor antagonists involved functionalization of a 2,5-disubstituted pyridine. We now report on construction of the pyridine core from commodity components. Shestopalov reported the synthesis of trans-4′-aryl-5′-cyano-1′,2′,3′, 4′-tetrahydro-6′-hydroxy-2′-oxo-1,3′-bipyridinium inner salts from 1-(2-amino-2-oxo-ethyl)pyridinium chloride, aromatic aldehydes, and ethyl cyanoacetate in the presence of a base. Reaction of these salts with phosphorus oxychloride affords 4-aryl-3-cyano-2,6-dichloropyridines. These are efficiently converted to nicotinamide precursors of the Roche NK-1 receptor antagonists by regioselective displacement of one chlorine by an amine, hydrogenolysis of the remaining chlorine, and nitrile hydrolysis.