34281-92-0 Usage
Description
(1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol is a white to light yellow crystalline powder with specific stereochemistry, characterized by its (1S,2R) configuration and (+) optical rotation. It is a cyclohexanol derivative featuring a phenyl group attached to the cyclohexane ring in a trans configuration.
Uses
Used in Pharmaceutical Research:
(1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol is used as a substrate for studying the permeability of alcohol enantiomers through imprinted membranes. This application is crucial in determining the permeability coefficient, which is an essential parameter in the development of drug delivery systems and understanding the behavior of chiral molecules in biological systems.
Used in Chemical Synthesis:
(1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol can be utilized as a chiral building block or intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique stereochemistry makes it a valuable component in creating enantiomerically pure compounds with specific biological activities.
Used in Analytical Chemistry:
(1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol can also be employed as a reference material or standard in analytical chemistry for the calibration of instruments and methods used in the separation and quantification of enantiomers, such as chiral chromatography and circular dichroism spectroscopy.
Used in Material Science:
The specific stereochemistry and chemical structure of (1S,2R)-(+)-trans-2-Phenyl-1-cyclohexanol may also find applications in the development of novel materials with tailored properties, such as chiral catalysts, sensors, or polymers with specific interactions and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 34281-92-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,8 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 34281-92:
(7*3)+(6*4)+(5*2)+(4*8)+(3*1)+(2*9)+(1*2)=110
110 % 10 = 0
So 34281-92-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H16O/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-3,6-7,11-13H,4-5,8-9H2/t11-,12+/m1/s1
34281-92-0Relevant articles and documents
Hydroboration. 80. Preparation of (trans-2-Phenylcyclopentyl)- and (trans-2-Phenylcyclohexyl)boronates of Very High Enantiomeric Purities
Brown, Herbert C.,Prasad, J. V. N. Vara,Gupta, Ashok K.,Bakshi, Raman K.
, p. 310 - 311 (1987)
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Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketonesviaPd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation
Luan, Pengqian,Liu, Yunting,Li, Yongxing,Chen, Ran,Huang, Chen,Gao, Jing,Hollmann, Frank,Jiang, Yanjun
, p. 1960 - 1964 (2021/03/26)
An aqueous chemoenzymatic cascade reaction combining Pd-catalyzed C-C formation and enzymatic C=C asymmetric hydrogenation (AH) was developed for enantioselective synthesis of tertiary α-aryl cycloketones in good yields and excellent enantioselectivities. The stereopreference of the enzyme in AH of α-aryl cyclohexenones was studied. An enantiocomplementary enzyme was obtained by site-directed mutation.
Preparation method of (1S, 2R)-2-phenylcyclohexanol
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Paragraph 0011-0013; 0015-0018, (2020/06/02)
The invention provides a preparation method of (1S, 2R)-2-phenylcyclohexanol. The preparation method specifically comprises the following steps: mixing and reacting a cyclohexene oxide solution, a tetrahydrofuran solution of phenyl magnesium bromide, and cuprous chloride or cuprous bromide for 1-3 h, and performing quenching treatment with an aqueous saturated ammonium chloride or saturated ammonium sulfate solution; and collecting the obtained upper organic layer, carrying out concentration, distillation and recrystallization treatment to obtain a raceme of chiral 2-phenylcyclohexanol, and carrying out resolution treatment on the raceme of chiral 2-phenylcyclohexanol to obtain (1S, 2R)-2-phenylcyclohexanol. The method allows the ee value of the obtained product to reach 98% or above, theprocess is simple, and the product purity is high.