3434-76-2 Usage
Description
3-O-Methyl 17α-Estradiol is an estradiol derivative, which is a type of steroid hormone. It is a white solid and is known for its antioxidant activity. 3-O-Methyl 17α-Estradiol is structurally similar to estradiol, a primary female sex hormone, but with a methyl group added to the 3-O position. The addition of the methyl group provides protection to the molecule, making it more stable and potentially enhancing its properties for various applications.
Uses
Used in Pharmaceutical Industry:
3-O-Methyl 17α-Estradiol is used as a pharmaceutical compound for its antioxidant properties. It can be employed in the development of drugs targeting conditions where oxidative stress plays a significant role, such as neurodegenerative diseases, cardiovascular diseases, and certain types of cancer.
Used in Research and Development:
In the field of research and development, 3-O-Methyl 17α-Estradiol serves as a protected 3-Methoxyestradiol-d5. This protected derivative is valuable for studying the structure-activity relationships of estradiol and its analogs, which can lead to the discovery of new therapeutic agents with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
As a white solid with specific chemical properties, 3-O-Methyl 17α-Estradiol can be used as an intermediate in the synthesis of other steroidal compounds. Its antioxidant activity and structural stability make it a useful building block for creating novel molecules with potential applications in various industries, including pharmaceuticals, cosmetics, and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 3434-76-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,3 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3434-76:
(6*3)+(5*4)+(4*3)+(3*4)+(2*7)+(1*6)=82
82 % 10 = 2
So 3434-76-2 is a valid CAS Registry Number.
3434-76-2Relevant articles and documents
Direct Synthesis of α-Amino Nitriles from Sulfonamides via Base-Mediated C-H Cyanation
Shi, Shasha,Yang, Xianyu,Tang, Man,Hu, Jiefeng,Loh, Teck-Peng
supporting information, p. 4018 - 4022 (2021/05/26)
Herein, we disclose a transition-metal-free reaction system that enables α-cyanation of sulfonamides through C-H bond cleavage for the preparation of α-amino nitriles, including difficult-to-access all-alkyl α-tertiary scaffolds. More than 50 substrate examples prove a wide functional group tolerance. Additionally, its synthetic practicality is highlighted by gram-scalability and the late-stage modification of natural compounds. Mechanistic experiments suggest that this process involves in situ formation of an imine intermediate via base-promoted elimination of HF.
A simple and convenient synthesis of 2-methoxyestradiol from estrone
Prakasham,Shanker, Karuna,Negi, Arvind S.
scheme or table, p. 467 - 470 (2012/05/19)
A simple and straightforward synthesis of 2-methoxyestradiol have been achieved in nine synthetic steps with 21% of overall yield. Being a convenient process, it can be upscaled to industrial process.
Transition metal-catalyzed intramolecular [4+2] cycloadditions: Mechanistic and synthetic investigations
Wender, Paul A.,Smith, Thomas E.
, p. 1255 - 1275 (2007/10/03)
The nickel-catalyzed intramolecular cycloaddition of dienes with unactivatable alkynes is found to proceed under mild conditions while the corresponding Diels-Alder cycloaddition of the same substrates either fails of occurs only under forcing conditions. The nickel-catalyzed cycloaddition is also shown to occur with retention of stereochemistry and is not significantly influenced by electronic effects. Finally, the catalyzed process is shown to be applicable to the synthesis of angularly substituted bicycles, including the CD ring systems of steroids and vitamin D.
