34469-10-8Relevant articles and documents
The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation
Guo, Huan,Li, Jing,Liu, Delong,Zhang, Wanbin
, p. 3665 - 3673 (2017)
A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).
ON CARBONYL PARTICIPATION IN THE SOLVOLYSES OF α-KETO MESYLATES
Creary, Xavier,McDonald, Steven R.,Eggers, Mark D.
, p. 811 - 814 (2007/10/02)
α-amido mesylates generally solvolyze giving α-keto cations, bypassing cyclic ions derived from carbonyl (kΔ) participation.A possible exception is the N,N-dimethylamido mesylate derived from (S)-mandelic acid in trifluoroacetic acid which gives a small amount (9percent) of retained product.
