3450-80-4

Basic information

• Product Name: 3,6-Dihydroxycoumarin
• Synonyms: 3,6-Dihydroxy-2H-1-benzopyran-2-one;3,6-Dihydroxycoumarin
• CAS NO: 3450-80-4
• Molecular Formula: C9H6O4
• Molecular Weight: 178.14154
• Mol File: 3450-80-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,6-Dihydroxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Dihydroxycoumarin(3450-80-4)
• EPA Substance Registry System: 3,6-Dihydroxycoumarin(3450-80-4)

Safety Data

• Hazardous Substances Data: 3450-80-4(Hazardous Substances Data)

Upstream product

• 782503-76-8 (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 782503-80-4 (Z)-3-(2,5-Dimethoxy-phenyl)-2-hydroxy-acrylic acid 

Relevant articles and documents

Antioxidant properties of 3-hydroxycoumarin derivatives

A series of hydroxylated 3-hydroxycoumarins was synthesised and evaluated for their antioxidant properties. The compounds substituted on the C-7 position were almost as antioxidant as quercetin or vitamin C. The antioxidant properties were related by an EPR study to their abilities to give stable semiquinonic or polyhydroxylated radicals. A series of hydroxylated 3-hydroxycoumarins was synthesised by the reaction of 3-aryl-2-hydroxypropenoic derivatives with boron tribromide. They were evaluated for their ability to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical, the superoxide anion radical, the hydroxyl radical and the peroxynitrite anion and to inhibit copper-induced human LDL peroxidation. The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C. These compounds form o- and p-quinonoid derivatives upon radical scavenging and may serve as new lead compounds for pharmacological investigations.