782503-76-8

Basic information

• Product Name: (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one
• Synonyms: (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one
• CAS NO: 782503-76-8
• Molecular Weight: 247.251
• Mol File: 782503-76-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one(782503-76-8)
• EPA Substance Registry System: (Z)-4-(2,5-dimethoxybenzylidene)-2-methyloxazol-5(4H)-one(782503-76-8)

Safety Data

• Hazardous Substances Data: 782503-76-8(Hazardous Substances Data)

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 543-24-8 N-acetylglycine 

Downstream Products

• 1338081-21-2 (Z)-5-(2-hydroxy-5-methoxybenzylidene)-2,3-dimethyl-3,5-dihydro-4H-imidazol-4-one 
• 1246401-08-0 (Z)-4-(2,5-dimethoxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one 
• 3450-80-4 3,6-Dihydroxy-cumarin 
• 56172-36-2 5-Hydroxybenzofuran-2-carboxylic acid 
• 782503-80-4 (Z)-3-(2,5-Dimethoxy-phenyl)-2-hydroxy-acrylic acid 
• 116632-49-6 (2,5-dimethoxy-phenyl)-pyruvic acid 

Relevant articles and documents

Antioxidant properties of 3-hydroxycoumarin derivatives

A series of hydroxylated 3-hydroxycoumarins was synthesised and evaluated for their antioxidant properties. The compounds substituted on the C-7 position were almost as antioxidant as quercetin or vitamin C. The antioxidant properties were related by an EPR study to their abilities to give stable semiquinonic or polyhydroxylated radicals. A series of hydroxylated 3-hydroxycoumarins was synthesised by the reaction of 3-aryl-2-hydroxypropenoic derivatives with boron tribromide. They were evaluated for their ability to scavenge the 2,2-diphenyl-1-picrylhydrazyl radical, the superoxide anion radical, the hydroxyl radical and the peroxynitrite anion and to inhibit copper-induced human LDL peroxidation. The physicochemical results were in accordance to establish the compounds hydroxylated on C-6 and C-7 positions as the most active of the series with antioxidant potencies comparable to those of quercetin and vitamin C. These compounds form o- and p-quinonoid derivatives upon radical scavenging and may serve as new lead compounds for pharmacological investigations.

Deracemisation of aryl substituted α-hydroxy esters using Candida parapsilosis ATCC 7330: Effect of substrate structure and mechanism

Candida parapsilosis ATCC 7330 was found to be an efficient biocatalyst for the deracemisation of aryl α-hydroxy esters (65-85% yield and 90-99% ee). A variety of aryl and aryl substituted α-hydroxy esters were synthesized to reflect steric and electronic effects on biocatalytic deracemisation. The mechanism of this biocatalytic deracemisation was found to be stereoinversion.