3460-23-9

Basic information

• Product Name: 4-BROMO-2-CHLOROACETANILIDE
• Synonyms: SALOR-INT L168270-1EA;4'-BROMO-2'-CHLOROACETANILIDE;4-BROMO-2-CHLOROACETANILIDE;BUTTPARK 83\07-60;4-Bromo-2-chloroacetanilide, 98+%;4'-Bromo-2'-chloro-N-phenylacetamide
• CAS NO: 3460-23-9
• Molecular Formula: C₈H₇BrClNO
• Molecular Weight: 248.5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Anilines, Amides & Amines;Bromine Compounds;Chlorine Compounds
• Mol File: 3460-23-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 151-152°C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in hot methanol (very faint turbidity).
• BRN: 2719133
• CAS DataBase Reference: 4-BROMO-2-CHLOROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-CHLOROACETANILIDE(3460-23-9)
• EPA Substance Registry System: 4-BROMO-2-CHLOROACETANILIDE(3460-23-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37
• Hazardous Substances Data: 3460-23-9(Hazardous Substances Data)

Usage

Uses

It is employed as a intermediate for pharmaceutical.

Upstream product

• 533-17-5 N-(2-chlorophenyl)acetamide 
• 38762-41-3 2-chloro-4-bromoaniline 
• 75-36-5 acetyl chloride 
• 106-40-1 4-bromo-aniline 
• 74114-62-8 4-acetamido-3-chlorobenzoic acid 
• 91631-56-0 N-sulfonoxy-p-bromoacetanilide pyridinium salt 
• 7647-01-0 hydrogenchloride 
• 103-88-8 4-bromoacetanilide 
• 127-65-1 chloroamine-T 
• 10035-10-6 hydrogen bromide 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 95-51-2 o-chloroaniline 
• 99233-16-6 acetic acid-(N-bromo-2-chloro-anilide) 

Downstream Products

• 878672-11-8 C₁₁H₁₂ClNO 
• 1059705-70-2 C₁₃H₁₈ClN₃O 
• 5304-21-2 6-bromo-2-methylbenzothiazole 
• 113570-93-7 4-Bromo-2-chlorothioacetanilide 
• 88142-15-8 4,6-Dibromo-2-chloroacetanilide 
• 38762-41-3 2-chloro-4-bromoaniline 
• 34033-41-5 2-chloro-4-bromo-6-nitroaniline 

Relevant articles and documents

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.

A Visible Light-Mediated Regioselective Halogenation of Anilides and Quinolines by Using a Heterogeneous Cu-MnO Catalyst

A simple and practical heterogeneous Cu-MnO catalyzed regioselective halogenation of anilides and quinolines under irradiation with household 40 W incandescent lamp was developed. This method uses a recyclable Cu-MnO catalyst, acetonitrile as an industrially friendly solvent, and economic N-halo succinimides as a halogenating source. The reaction is scalable and well tolerated with a broad range of functional groups.

Monoprotected l-Amino Acid (l-MPAA), Accelerated Bromination, Chlorination, and Iodination of C(sp2)?H Bonds by Iridium(III) Catalysis

Halogenated arenes are important structural motifs commonly found in biologically active molecules and used for a variety of transformations in organic synthesis. Herein, we report the mono-protected l-amino acid (l-MPAA) accelerated iridium(III)-catalyzed halogenation of (hetero)anilides at room temperature. This reaction constitutes the first example of an iridium(III)/l-MPAA-catalyzed general halogenation of (hetero)arenes through C(sp2)?H activation. Furthermore, we demonstrate the potential utility of our method through its use in the synthesis of a quinolone derivative.