347-54-6

Basic information

• Product Name: 5-Fluorosalicylaldehyde
• Synonyms: 5-FLUORO-2-HYDROXYBENZALDEHYDE;5-FLUOROSALICYLALDEHYDE;5-Fluoro-2-Hydroxybenzaldehyde 5-Fluoro Salicylic Aldehyde;5-Fluoro-2-hydroxybenzaldehyde,97%;5-FluoroSalicylicAldehyde;5-FLUORO-2-HYDROXYBENZALDEHYDE, 98+%;5-Fluorosalicylaldehyde, 98+%;5-Fluorosalicylaldehyde, 4-Fluoro-2-formylphenol
• CAS NO: 347-54-6
• Molecular Formula: C₇H₅FO₂
• Molecular Weight: 140.11
• EINECS: 1533716-785-6
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde
• Mol File: 347-54-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 82-85 °C(lit.)
• Boiling Point: 56 °C / 1mmHg
• Flash Point: 79.2 °C
• Appearance: /Powder or Flakes
• Density: 1.35 g/cm³
• Vapor Pressure: 3.3mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.18±0.18(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 5-Fluorosalicylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluorosalicylaldehyde(347-54-6)
• EPA Substance Registry System: 5-Fluorosalicylaldehyde(347-54-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 347-54-6(Hazardous Substances Data)

Usage

Description

5-Fluorosalicylaldehyde is an organic compound derived from 4-fluorophenol, characterized by its white solid appearance. It serves as a crucial intermediate in the synthesis of various complex molecules and has potential applications in different industries due to its unique chemical properties.

Uses

Used in Chemical Synthesis:
5-Fluorosalicylaldehyde is used as a key intermediate for the synthesis of complex organic molecules, such as manganese (III) complexes, enantiopure chromanes, and various other organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse applications.
Used in Pharmaceutical Industry:
5-Fluorosalicylaldehyde is used as a building block for the development of new pharmaceutical compounds. Its role in synthesizing various organic molecules makes it a valuable asset in the design and production of novel drugs with potential therapeutic applications.
Used in Material Science:
In the field of material science, 5-Fluorosalicylaldehyde can be utilized in the synthesis of advanced materials with specific properties. Its ability to form complexes and contribute to the development of new compounds makes it a promising candidate for creating materials with tailored characteristics for various applications.
Used in Research and Development:
5-Fluorosalicylaldehyde is used as a research compound for exploring new chemical reactions and understanding the behavior of different molecules. Its unique properties make it an essential tool in the hands of chemists and researchers working on the development of new chemical processes and applications.

InChI:InChI=1/C7H6F3NS/c8-7(9,10)12-6-4-2-1-3-5(6)11/h1-4H,11H2

Upstream product

• 371-41-5 4-Fluorophenol 
• 67-66-3 chloroform 
• 50-00-0 formaldehyd 
• 19415-51-1 5-fluoro-2-methoxybenzaldehyde 
• 452-72-2 4-fluoro-2-methylphenol 
• 91407-40-8 5-fluoro-2-hydroxybenzaldehyde oxime 
• 76-05-1 trifluoroacetic acid 
• 459-60-9 1-fluoro-4-methoxybenzene 
• 1998-90-9 2-acetoxy-5-fluoro benzyl acetate 
• 2357-33-7 5-fluoro-2-hydroxy-benzyl alcohol 
• 496-69-5 2-bromo-4-fluoro-phenol 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 1054643-58-1 (2S,3S,4S,5R,6S)-3,4,5-Triacetoxy-6-(4-fluoro-2-formyl-phenoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 345-16-4 5-fluoro-2-hydroxybenzoic acid 
• 863288-39-5 methyl (E)-3-(5-fluoro-2-hydroxyphenyl)acrylate 
• 875925-94-3 benzyl-(8-fluoro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-yl)-amine 
• 949449-09-6 3-(5-fluoro-2-hydroxyphenyl)acrylic acid ethyl ester 
• 946134-86-7 5-fluoro-2-[4-(trifluoromethyl)benzyloxy]benzaldehyde 
• 946134-94-7 C₁₅H₁₁ClF₄O 
• 946134-98-1 C₂₇H₂₄F₄O₄S 
• 946134-90-3 C₁₅H₁₂F₄O₂ 
• 1193392-77-6 5-fluoro-2-(oxiran-2-ylmethoxy)benzaldehyde 
• 1162642-05-8 (4R)-4-(5-fluoro-2-hydroxy-phenyl)-4-hydroxy-butan-2-one 
• 1245631-52-0 C₁₄H₁₂FN₃O 
• 1096888-64-0 2-(but-3-enyloxy)-5-fluorobenzaldehyde 
• 93849-31-1 ethyl 5-fluoro-1H-benzofuran-2-carboxylate 

Relevant articles and documents

Benzimidazole Based ‘Turn on’ Fluorescent Chemodosimeter for Zinc Ions in Mixed Aqueous Medium

Benzimidazole based compound 3 is designed and synthesized. The compound 3 is evaluated as fluorogenic sensor for metal ions in mixed aqueous solutions. Among all the metal ions tested, the compound 3 selectively senses Zn2+ ions. The imine bond of 3 gets cleaved by Zn2+ ions. Thus, 3 behave as ‘turn on’ fluorescent chemodosimeter for Zn2+ ions with limit of detction in micromolar range. Furthurmore, we demonstated that 3 can detect Zn2+ ions in cells of Allium cepa. [Figure not available: see fulltext.]

Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

Effects of Substituents on Metastable-State Photoacids: Design, Synthesis, and Evaluation of their Photochemical Properties

Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituents have a great influence on the photochemical properties of molecules, which will further affect their applications. Yet, the effects of substituents on metastable-state photoacids have not been studied systematically. In this work, 16 metastable-state photoacid derivatives were designed and synthesized on the basis of substituents having a large range of σ–π electron–donor–acceptor capabilities. The effects of substituents on the color display [or maximum absorption band(s)], solubility, pKa values, dark/photoacidity, photosensitivity, and relaxation kinetic(s) were investigated in detail. This study will be helpful for the targeted design and synthesis of promising photoacids and the application of their photocontrolled proton-release processes in functional materials/devices.