34857-28-8

Basic information

• Product Name: (S)-(-)-2-METHYL-1-PHENYL-1-PROPANOL
• Synonyms: (S)-2-METHYL-1-PHENYLPROPAN-1-OL;(S)-(-)-2-METHYL-1-PHENYLPROPANOL;(S)-(-)-2-METHYL-1-PHENYL-1-PROPANOL;(S)-(-)-2-Methyl-1-phenyl-1-propanol ,≥98%, ≥97% ee (GLC, chiral column: Chirasil-dex CB);(1S)-1-Phenyl-2-methyl-1-propanol;(S)-α-Isopropylbenzyl alcohol;(αS)-α-Isopropylbenzenemethanol;[S,(-)]-α-Isopropylbenzyl alcohol
• CAS NO: 34857-28-8
• Molecular Formula: C₁₀H₁₄O
• Molecular Weight: 150.22
• Product Categories: Chiral Compound
• Mol File: 34857-28-8.mol
• Article Data: 199

Chemical Properties

• Boiling Point: 219.8°Cat760mmHg
• Flash Point: 86.7°C
• Appearance: /
• Density: 0.976g/cm³
• Vapor Pressure: 0.0678mmHg at 25°C
• Refractive Index: 1.517
• PKA: 14.29±0.20(Predicted)
• CAS DataBase Reference: (S)-(-)-2-METHYL-1-PHENYL-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-METHYL-1-PHENYL-1-PROPANOL(34857-28-8)
• EPA Substance Registry System: (S)-(-)-2-METHYL-1-PHENYL-1-PROPANOL(34857-28-8)

Safety Data

• Statements: R22:Harmful if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 34857-28-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C10H14O/c1-8(2)10(11)9-6-4-3-5-7-9/h3-8,10-11H,1-2H3/t10-/m0/s1

Upstream product

• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 557-20-0 diethylzinc 
• 100-52-7 benzaldehyde 
• 920-39-8 isopropylmagnesium bromide 
• 81978-46-3 (1R,2S,4S,6S,7R)-1,10,10-Trimethyl-4-(2-methyl-1-phenyl-propoxy)-3-oxa-tricyclo[5.2.1.0^2,6]decane 
• 108-86-1 bromobenzene 
• 78-84-2 isobutyraldehyde 
• 538-93-2 1-phenyl-2-methylpropane 
• 1068-55-9 isopropylmagnesium chloride 
• 611-69-8 rac-2-methyl-1-phenylpropan-1-ol 
• 97-72-3 2-Methylpropionic anhydride 
• 93-55-0 1-phenyl-propan-1-one 
• 769-60-8 2-methyl-1-phenylprop-2-en-1-one 
• 625-81-0 diisopropyl zinc 

Downstream Products

• 128864-59-5 (R)-Fluoro-phenyl-acetic acid (S)-2-methyl-1-phenyl-propyl ester 
• 171334-35-3 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-2-methyl-1-phenyl-propyl ester 
• 182691-23-2 (S)-carbonic acid 2-methyl-1-phenylpropyl ester 4-nitrophenyl ester 
• 2376521-83-2 C₄₂H₅₂O₄P₂ 
• 104464-04-2 (1S,4R,8S)-8-(2-Methyl-1-phenyl-propoxy)-4-(toluene-4-sulfonyl)-2-oxa-bicyclo[2.2.2]oct-5-en-3-one 
• 106968-30-3 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 2-methyl-1-phenyl-propyl ester 
• 136476-12-5 [(S)-2-Methyl-1-((E)-2-methyl-buta-1,3-dienyloxy)-propyl]-benzene 
• 175522-75-5 [(R)-2-Methyl-1-((E)-2-methyl-buta-1,3-dienyloxy)-propyl]-benzene 
• 176436-00-3 (S)-3-(2,3-Difluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester 
• 176435-85-1 (R)-3-(2,3-Difluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester 
• 176436-02-5 (S)-3-(2,3-Difluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid 
• 176435-88-4 (R)-3-(2,3-Difluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid 
• 176435-84-0 (R)-3-(2-Fluoro-phenyl)-2-methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-propionic acid methyl ester 
• 176435-99-7 (R)-2-Methyl-2-((S)-2-methyl-1-phenyl-propoxycarbonylamino)-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

Alkylmetal Asymmetric Reduction. 10. Reaction of β-Branched Alkylaluminum Halides with Isopropyl Phenyl Ketone

The reaction of isobutylaluminum halides with isopropyl phenyl ketone has been studied in diethyl ether at 0 deg C.It has been shown that the diisobutylaluminum halides rapidly reduce the ketone to the corresponding carbinol, while the sesquihalides and t

Amino Acid-Functionalized Metal-Organic Frameworks for Asymmetric Base–Metal Catalysis

We report a strategy to develop heterogeneous single-site enantioselective catalysts based on naturally occurring amino acids and earth-abundant metals for eco-friendly asymmetric catalysis. The grafting of amino acids within the pores of a metal-organic framework (MOF), followed by post-synthetic metalation with iron precursor, affords highly active and enantioselective (>99 % ee for 10 examples) catalysts for hydrosilylation and hydroboration of carbonyl compounds. Impressively, the MOF-Fe catalyst displayed high turnover numbers of up to 10 000 and was recycled and reused more than 15 times without diminishing the enantioselectivity. MOF-Fe displayed much higher activity and enantioselectivity than its homogeneous control catalyst, likely due to the formation of robust single-site catalyst in the MOF through site-isolation.

Enantioselective α-Arylation of Primary Alcohols under Sequential One-Pot Catalysis

Secondary benzylic alcohols and diarylmethanols are common structural motifs of biologically active and medicinally relevant compounds. Here we report their enantioselective synthesis by α-arylation of primary aliphatic and benzylic alcohols under sequential catalysis integrating a Ru-catalyzed hydrogen transfer oxidation and a Ru-catalyzed nucleophilic addition. The method can be applied to various alcohols and aryl nucleophiles tolerating a range of functional groups, including secondary alcohols, ketones, alkenes, esters, NH amides, tertiary amines, aryl halides, and heterocycles.