349-00-8 Usage
Description
N-(trifluoroacetyl)valine is a synthetic chemical compound with the molecular formula C7H10F3NO3. It is a derivative of valine, an essential amino acid that plays a crucial role in protein synthesis and muscle growth. The trifluoroacetyl group is a strong electron-withdrawing group, which can enhance the acidity, reactivity, and physicochemical properties of the compound.
Uses
Used in Organic Synthesis:
N-(trifluoroacetyl)valine is used as a building block for the preparation of peptide-based drugs and biologically active molecules, contributing to the development of new pharmaceutical agents.
Used in Pharmaceutical Research:
N-(trifluoroacetyl)valine is used as a research tool for studying the structure-activity relationships of various bioactive compounds, aiding in the discovery of novel drug candidates.
Used in Medicinal Chemistry:
N-(trifluoroacetyl)valine is used for the development of new drugs with improved pharmacokinetic and pharmacodynamic properties, enhancing the therapeutic potential of medications.
Used in Drug Design:
N-(trifluoroacetyl)valine is utilized in the design of drugs with enhanced reactivity and physicochemical properties, due to the electron-withdrawing effect of the trifluoroacetyl group.
Check Digit Verification of cas no
The CAS Registry Mumber 349-00-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 349-00:
(5*3)+(4*4)+(3*9)+(2*0)+(1*0)=58
58 % 10 = 8
So 349-00-8 is a valid CAS Registry Number.
349-00-8Relevant articles and documents
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Kricheldorf,H.R.,Fehrle,M.
, p. 420 - 422 (1974)
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The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines
Wang, Ke,Lu, Yanhui,Ishihara, Kazuaki
supporting information, p. 5410 - 5413 (2018/05/30)
2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.
Synthesis of dipeptides based on valine and threonine
Sorokina, Yu. M.,Sladkova,Popova,Shadyro,Knizhnikov
, p. 1297 - 1301 (2013/02/21)
Val-Val, Val-Thr, and Thr-Val dipeptides were synthesized using trifluoroacetyl protecting group. The optical rotations of the products were similar to those of samples synthesized using Boc protection, which indicated the absence of racemization in the course of introduction and removal of trifluoroacetyl protection. Pleiades Publishing, Ltd., 2012.