3490-92-4Relevant articles and documents
HEADGROUP LIPID COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
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Paragraph 00411, (2021/04/01)
The application relates to lipids of Formula (A-1) and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include such a lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/ or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Pyrano[3,2-c] julolidin-2-ones: A novel class of fluorescent probes for ratiometric detection and imaging of Hg2+ in live cancer cells
Jha, Ajay Kumar,Umar, Shahida,Arya, Rakesh Kumar,Datta, Dipak,Goel, Atul
, p. 4934 - 4940 (2016/07/26)
A novel pyrano[3,2-c]julolidin-2-one based fluorescent molecular rotor PYJO4 has been designed and developed for selective ratiometric detection, quantification and imaging of intracellular Hg2+ in live cells. The probe operates via a Twisted Intramolecular Charge Transfer (TICT) mechanism and exhibits high selectivity and sensitivity up to 1.14 ppb. PYJO4 coated test strips can be used to detect mercury ions in contaminated water.
Design and synthesis of potent N-phenylpyrimidine derivatives for the treatment of skin cancer
Chaube, Udit J.,Vyas, Vivek K.,Bhatt, Hardik G.
, p. 10285 - 10297 (2016/02/09)
The development of novel synthetic compounds for the treatment of skin cancer is much needed, as there is a sudden rise in the incidence of skin cancer throughout the world and the available chemotherapy is facing problems of resistance. Hence, present re