34953-87-2

Basic information

• Product Name: 4-Pyrimidinemethanol, 2-chloro- (9CI)
• Synonyms: 4-Pyrimidinemethanol, 2-chloro- (9CI);4-Pyrimidinemethanol, 2-chloro-;(2-chloropyrimidin-4-yl)methanol
• CAS NO: 34953-87-2
• Molecular Formula: C₅H₅ClN₂O
• Molecular Weight: 144.559
• Product Categories: PYRIMIDINE
• Mol File: 34953-87-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 341.8±17.0 °C(Predicted)
• Appearance: /
• Density: 1.422±0.06 g/cm3(Predicted)
• PKA: 13.05±0.10(Predicted)
• CAS DataBase Reference: 4-Pyrimidinemethanol, 2-chloro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinemethanol, 2-chloro- (9CI)(34953-87-2)
• EPA Substance Registry System: 4-Pyrimidinemethanol, 2-chloro- (9CI)(34953-87-2)

Safety Data

• Hazardous Substances Data: 34953-87-2(Hazardous Substances Data)

Usage

General Description

4-Pyrimidinemethanol, 2-chloro- (9CI) is a chemical compound with the molecular formula C5H5ClN2O. It is a chlorinated derivative of 4-pyrimidinemethanol, and its structure includes a pyrimidine ring with a hydroxyl group and a chlorine atom attached to it. 4-Pyrimidinemethanol, 2-chloro- (9CI) is commonly used in the pharmaceutical industry as a building block for the synthesis of various medications. It may also have applications in organic synthesis and chemical research. Additionally, it is important to handle this chemical with care, as it may pose health and environmental risks if not used properly.

Upstream product

• 149849-92-3 2‐chloropyrimidine‐4‐carboxylic acid 
• 149849-94-5 methyl 2,6-dichloropyrimidine-4-carboxylate 

Downstream Products

• 181363-06-4 4-(bromomethyl)-2-chloropyrimidine 

Relevant articles and documents

MCL1 INHIBITORS AND USES THEREOF

The present disclosure provides compounds, such as compounds of Formula I, and compositions that are MCL1 inhibitors.

PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer, immune disorders and other diseases. Formula (I).

2,3-DISUBSTITUTED 1 -ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS

The present invention relates to novel compounds of formula (I), wherein R1 is C1-4alkyl; R2 is C1-4alkyl, C3-7cycloalkyl, -CH2CF3, -CH2OCH3 or heterocyclyl; R3 is C1-4alkyl, -CH2F, -CH2OH or -CH2O(O)CH3; R4 when present is as defined in claim 1; R5 when present is H, halo, hydroxy or C1-6alkoxy; A is -NH-, -O-, -S-, -SO-, -SO2-, -N(C1-4alkyl)- or -NC(O)(CH3)-; V is phenyl, heteroaromatic or pyridone any of which may be optionally substituted by 1, 2 or 3 substituents; W is CH or N; X is C or N; Y is C or N; and Z is CH or N; subject to the proviso that no more than 2 of W, X, Y and Z are N, pharmaceutical compositions containing such compounds and to their use as bromodomain inhibitors.