149849-94-5 Usage
Description
Methyl 2-chloropyrimidine-4-carboxylate is an organic ester derived from pyrimidine, a heterocyclic compound with a wide range of applications in the pharmaceutical industry. It is characterized by the presence of a chlorine atom at the 2nd position and a carboxylate group at the 4th position, which contributes to its reactivity and utility in chemical synthesis.
Uses
Used in Pharmaceutical Synthesis:
Methyl 2-chloropyrimidine-4-carboxylate is used as an intermediate in pharmaceutical synthesis for experimental research and the development of new drugs. Its unique chemical structure allows it to be a versatile building block in the creation of various pharmaceutical compounds, particularly those with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, methyl 2-chloropyrimidine-4-carboxylate serves as a valuable compound for exploring new reaction pathways and understanding the reactivity of pyrimidine derivatives. Its chlorine atom and carboxylate group can be further modified or functionalized to generate a diverse array of chemical products with potential applications in various industries.
Used in Drug Development:
Methyl 2-chloropyrimidine-4-carboxylate is also utilized in drug development, where it can be employed to create novel therapeutic agents with improved efficacy, selectivity, and safety profiles. Its incorporation into drug candidates can lead to the discovery of new treatments for a range of diseases and conditions, including cancer, infectious diseases, and neurological disorders.
Synthesis
Synthesis of methyl 2-chloropyrimidine-4-carboxylate: 2-chloropyrimidine-4-carboxylic acid (4.76 g, 30 mmol) was dissolved in dichloromethane (30 mL) and dimethylformamide (0.3 mL), to which was added Slowly add oxalyl chloride (5.72g, 45mmol) dropwise, stir at room temperature for 2 hours, lookchem, after concentrating to an appropriate volume, add dropwise to anhydrous methanol (50mL) placed under ice bath conditions, after the dropwise addition, the reaction is transferred to The reaction was carried out at room temperature for 2 hours, and concentrated under reduced pressure to obtain (5.17 g, yield 100%).
Check Digit Verification of cas no
The CAS Registry Mumber 149849-94-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,8,4 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 149849-94:
(8*1)+(7*4)+(6*9)+(5*8)+(4*4)+(3*9)+(2*9)+(1*4)=195
195 % 10 = 5
So 149849-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClN2O2/c1-11-5(10)4-2-3-8-6(7)9-4/h2-3H,1H3
149849-94-5Relevant articles and documents
HETEROCYCLIC AMIDES AS KINASE INHIBITORS
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Page/Page column 165; 166, (2018/06/06)
Disclosed are compounds having the formula: wherein R1 and R2 are as defined herein, and methods of making and using the same.
Products of a microbiological process for the production of 2-halo-pyrimidine-4-carboxylic acids
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, (2008/06/13)
A 2-halo-pyrimidine-4-carboxylic acid of formula: STR1 wherein X is a halogen atom, for example, 2-chloro-pyrimidine-4-carboxylic acid. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula: STR2 wherein R1 is a halogen atom, NH2 --, HO-- or a C1 -C4 alkoxy group and R2 is a C1 -C4 alkoxy group or a halogen atom with the proviso that, if R1 is a HO-- group, R2 is not a halogen atom and with the proviso that, if R2 is a halo group, R1 is not an amino group. A 2-substituted-pyrimidine-4-carboxylic acid derivative of formula III wherein R1 is a HO-- group and R2 is an ethoxy group.
