350604-58-9

Basic information

• Product Name: tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane
• Synonyms: tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane
• CAS NO: 350604-58-9
• Molecular Weight: 380.989
• Mol File: 350604-58-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane(CAS DataBase Reference)
• NIST Chemistry Reference: tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane(350604-58-9)
• EPA Substance Registry System: tetr-butyl(4-chloro-3-methylphenoxy)diphenylsilane(350604-58-9)

Safety Data

• Hazardous Substances Data: 350604-58-9(Hazardous Substances Data)

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 288-32-4 1H-imidazole 

Downstream Products

• 350604-59-0 [3-(bromomethyl)-4-chlorophenoxy](tert-butyl)diphenylsilane 
• 423166-05-6 2-[(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)amino]ethanol 
• 423166-08-9 N-(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)-1-(4-cyano-3-fluorobenzyl)-N-(2-oxoethyl)-1H-imidazole-5-carboxamide 
• 423166-07-8 N-(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)-1-(4-cyano-3-fluorobenzyl)-N-(2-hydroxyethyl)-1H-imidazole-5-carboxamide 
• 423166-09-0 4-[(5-{[(2R)-4-(5-{[tert-butyl(diphenyl)silyl]oxy}-2-chlorobenzyl)-2-methyl-3-oxopiperazin-1-yl]carbonyl}-1H-imidazol-1-yl)methyl]-2-fluorobenzonitrile 

Relevant articles and documents

Inhibitors of prenyl-protein transferase

The present invention is directed to peptidomimetic macrocyclic compounds of the formula A: wherein W is a heterocycle, V is a heterocycle or aryl moiety and Z1is a suitably substituted aryl or heterocycle moiety. The instant compounds inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.