352200-57-8

Basic information

• Product Name: N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione
• Synonyms: N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione
• CAS NO: 352200-57-8
• Molecular Weight: 416.008
• Mol File: 352200-57-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione(352200-57-8)
• EPA Substance Registry System: N-(5-methyl-1-phenyl-4-hexen-1-oxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione(352200-57-8)

Safety Data

• Hazardous Substances Data: 352200-57-8(Hazardous Substances Data)

Upstream product

• 4528-19-2 5-Methyl-1-phenyl-4-hexen-1-ol 
• 80325-42-4 6-Chloro-2-methyl-6-phenyl-2-hexene 

Downstream Products

• 2104-00-9 4-(4'-chloro)-phenyl-Δ-4-thiazolene-2-thione 
• 4535-64-2 5-methyl-1-phenylhex-4-en-1-one 
• 4528-19-2 5-Methyl-1-phenyl-4-hexen-1-ol 
• 227082-35-1 2-(tributylstannyl)sulfanyl-4-(p-chlorophenyl)thiazole 

Relevant articles and documents

Microwave-assisted generation of alkoxyl radicals and their use in additions, β-fragmentations, and remote functionalizations

Microwave irradiation (2.45 GHz, 300-500 W) of N-(alkoxy)thiazole-2(3H)- thiones in low-absorbing solvents affords alkoxyl radicals, which were identified by (i) spin adduct formation (EPR-spectroscopy) and (ii) fingerprint-type selectivities in intramolecular additions (stereoselective synthesis of disubstituted tetrahydrofurans), β-fragmentations (formation of carbonyl compounds), and C,H-activation of aliphatic subunits, by δ-selective hydrogen atom transfer. C-Radicals formed from oxygen-centered intermediates were trapped either by Bu3SnH, l-cysteine ethyl ester, the reduced form of glutathione (reductive trapping), or by bromine atom donor BrCCl3 (heteroatom functionalization) The results suggest that microwave activation is superior to UV/Vis-photolysis and conductive heating for alkoxyl radical generation from N-(alkoxy)thiazolethiones. It offers by far the shortest reaction times along with the option to reduce the amount of trapping reagent significantly. The Royal Society of Chemistry 2006.