3524-33-2

Basic information

• Product Name: 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE
• Synonyms: 2-ETHYL-5-METHYL-2 H-PYRAZOL-3-YLAMINE;1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE;1-ETHYL-3-METHYLPYRAZOLE-5-YLAMINE;5-AMINO-1-ETHYL-3-METHYLPYRAZOLE;AKOS B022223;BUTTPARK 52\11-39;ART-CHEM-BB B022223;2-Ethyl-5-methyl-2 H -pyrazol-3-ylamine1-Ethyl-3-methyl-1 H -pyrazol-5-ylamine
• CAS NO: 3524-33-2
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.17
• Mol File: 3524-33-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 99-100°C
• Boiling Point: 246 °C at 760 mmHg
• Flash Point: 102.6 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.0278mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE(3524-33-2)
• EPA Substance Registry System: 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE(3524-33-2)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 3524-33-2(Hazardous Substances Data)

Usage

General Description

1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE is a chemical compound with the molecular formula C7H11N3. It is a pyrazole derivative with a substituent at the 1-position by an ethyl group and at the 3-position by a methyl group. 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE is commonly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical drugs and active ingredients. It has been studied for its potential biological activities, including its role as an antifungal and antimicrobial agent. The chemical properties and potential applications of 1-ETHYL-3-METHYL-1H-PYRAZOL-5-AMINE make it an important compound with potential for various industrial and medicinal uses.

InChI:InChI=1/C6H11N3/c1-3-9-6(7)4-5(2)8-9/h4H,3,7H2,1-2H3

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 624-80-6 ethylhydrazine 
• 109-75-1 but-3-enenitrile 
• 6629-60-3 ethylhydrazine oxalic acid salt 

Downstream Products

• 1453849-92-7 (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-ethyl-3-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 
• 1224887-11-9 2-({5-chloro-2-[(1-ethyl-3-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)-N-ethylbenzamide 
• 1224887-21-1 2-[5-cyclopropyl-2-(2-ethyl-5-methyl-2H-pyrazol-3-ylamino)-pyridin-4-ylamino]-N-methylbenzamide 
• 1224887-23-3 2-[5-cyclopropyl-2-(2-ethyl-5-methyl-2H-pyrazol-3-ylamino)-pyridin-4-ylamino]-N-methoxy-benzamide 
• 1224887-99-3 2-({5-chloro-2-[(1-ethyl-3-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)benzonitrile 
• 1224887-08-4 2-({5-chloro-2-[(1-ethyl-3-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)-N-(methyloxy)benzamide 
• 57860-95-4 N-(1-ethyl-3-methylpyrazol-5-yl)-anthranilic acid 
• 919100-29-1 2-chloro-N-(1-ethyl-3-methyl-1H-pyrazol-5-yl)acetamide 
• 57632-73-2 1-ethyl-3-methyl-6-phenyl-1,7-dihydro-pyrazolo[3,4-b]pyridin-4-one 
• 851520-85-9 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid 
• 37801-47-1 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 36980-13-9 4-chloro-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl chloride 

Relevant articles and documents

9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS

The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

Discovery of new orally active phosphodiesterase (PDE4) inhibitors

A series of 4-anilinopyrazolopyridine derivatives were synthesized and biologically evaluated as inhibitors of phosphodiesterase (PDE4). Chemical modification of 3, a structurally new chemical lead that was found in our in-house library, was focused on 1- and 3-substituents. Full details of the discovery of a new orally active chemical lead 5 are presented. Structure-activity relationship data, pharmacological evaluation, and the subtype selectivity study are also presented.

Substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof

Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing o