352695-78-4

Basic information

• Product Name: 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole
• Synonyms: 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole
• CAS NO: 352695-78-4
• Molecular Weight: 453.329
• Mol File: 352695-78-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole(352695-78-4)
• EPA Substance Registry System: 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole(352695-78-4)

Safety Data

• Hazardous Substances Data: 352695-78-4(Hazardous Substances Data)

Upstream product

• 352695-71-7 4-(2-bromo-1-fluoroethyl)-1-trityl-1H-imidazole 
• 86803-29-4 4-ethenyl-1-(triphenylmethyl)-1H-imidazole 

Downstream Products

• 352695-87-5 2,2-difluoro-2-(1-trityl-1H-imidazol-4-yl)-ethylamine 
• 352695-86-4 4-(2-azido-1,1-difluoroethyl)-1-trityl-1H-imidazole 

Relevant articles and documents

New building blocks for fluorinated imidazole derivatives: Preparation of β-fluoro- and β,β-difluorohistamine

We demonstrate that "FBr" addition to 1-trityl-4-vinyl-1H-imidazole (7) provides a convenient route to side-chain-fluorinated histamines. Thus, addition of "FBr" to the double bond of 7 occurs with Markovnikov regioselectivity to produce 4-(2-bromo-1-fluoroethyl)-1-trityl-1H-imidazole (8). Substitution with azide, reduction, and removal of the trityl group provide β-fluorohistamine (1) as the dihydrochloride. Elimination of HBr from 8 followed by a second addition of "FBr" gives 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole (15). This was similarly converted to β,β-difluorohistamine (2) as the dihydrochloride.