86803-29-4

Basic information

• Product Name: 1-trityl-4-vinyl-1H-imidazole
• Synonyms: 1-trityl-4-vinyl-1H-imidazole
• CAS NO: 86803-29-4
• Molecular Formula: C₂₄H₂₀N₂
• Molecular Weight: 336.429
• Mol File: 86803-29-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-trityl-4-vinyl-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-trityl-4-vinyl-1H-imidazole(86803-29-4)
• EPA Substance Registry System: 1-trityl-4-vinyl-1H-imidazole(86803-29-4)

Safety Data

• Hazardous Substances Data: 86803-29-4(Hazardous Substances Data)

Usage

Imidazole derivative

A heterocyclic compound with a five-membered ring containing three carbon atoms and two nitrogen atoms 1-Trityl-4-vinyl-1H-imidazole is derived from imidazole, which is a heterocyclic compound with a five-membered ring structure.

Trityl group

A protective group for the imidazole nitrogen atom The presence of a trityl group in the compound provides protection for the nitrogen atom, allowing for selective reactions to occur at other positions on the imidazole ring.

Vinyl group

Allows for further functionalization of the compound The vinyl group attached to the imidazole ring enables additional functionalization through various organic reactions.

Organic synthesis

Commonly used in organic synthesis 1-Trityl-4-vinyl-1H-imidazole is widely used as a building block for the preparation of various functionalized imidazole derivatives.

Versatile chemical compound

Applications in organic chemistry and material science The compound has a broad range of applications in both organic chemistry and material science due to its unique structure and reactivity.

Upstream product

• 3718-04-5 4⁽⁵⁾-vinyl imidazole 
• 76-83-5 trityl chloride 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 74-83-9 methyl bromide 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 75927-49-0 pinacol vinylboronate 
• 104-98-3 urocanic acid 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 117257-71-3 1-triphenylmethyl-4-(2-bromoethyl)imidazole 

Downstream Products

• 403485-94-9 C₄₄H₃₉ClN₄O₂S 
• 352695-86-4 4-(2-azido-1,1-difluoroethyl)-1-trityl-1H-imidazole 
• 352695-87-5 2,2-difluoro-2-(1-trityl-1H-imidazol-4-yl)-ethylamine 
• 352695-78-4 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole 
• 352695-85-3 4-(2-azido-1-fluoroethyl)-1-trityl-1H-imidazole 
• 352695-83-1 2-fluoro-2-(1-trityl-1H-imidazol-4-yl)ethylamine 
• 352695-76-2 4-(1-fluorovinyl)-1-trityl-1H-imidazole 
• 195053-92-0 1-(Triphenylmethyl)-4-(2-amino-1-ethyl)imidazole 
• 680186-45-2 (E)-2-bromo-3-fluoro-3-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-ol 
• 438206-68-9 (Z)-3-fluoro-3-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-ol 
• 680186-47-4 (1-trityl-1H-imidazol-4-yl)-propynoic acid ethyl ester 
• 680186-40-7 3-(1-trityl-1H-imidazol-4-yl)-prop-2-yn-1-ol 
• 680186-43-0 (Z)-4-(2-bromo-1-fluoroethenyl)-1-trityl-1H-imidazole 
• 680186-38-3 4-(ethynyl)-1-trityl-1H-imidazole 

Relevant articles and documents

Functionalization of the Imidazole Backbone by Means of a Tailored and Optimized Oxidative Heck Cross-Coupling

A general and selective Pd-catalyzed cross-coupling of aromatic boronic acids with vinyl-imidazoles is disclosed. Unlike most cross-coupling reactions, this method operates well in absence of bases avoiding the formation of by-products. The reactivity is highly enhanced by the presence of nitrogen-based ligands, in particular bathocuproine. The method involves MnO2 as oxidant for the oxidation Pd (0)→Pd (II), a much weaker oxidant than previously reported in the literature. This allows for the use of reactants that possess a multitude of functional groups. A scope and limitation study involving a series of 24 boronic acids, whereof 18 afforded TMs in yields in the range 41–95%. The disclosed method constitutes the first general method for the oxidative Heck cross-coupling on the imidazole scaffold, which moreover operates with a selection of other heterocycles. (Figure presented.).

TRIAZINE COMPOUNDS AS KINASE INHIBITORS

The present invention relates to triazine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to morpholino substituted triazines, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases or PI3 kinases. The compounds are of the formula (I)

The kulinkovich reaction in the synthesis of constrained N,N-dialkyl neurotransmitter analogues

An intermolecular Ti(IV)-mediated cyclopropanation reaction has been used to synthesize substituted 2-phenylcyclopropylamines and constrained analogues of the neurotransmitters histamine and tryptamine. Many hydroxy- and methoxy-substituted phenylcyclopropylamines are known to inhibit monoamine oxidase and have been shown to mimic hallucinogens. These compounds were made in 1 to 5 steps from readily available starting materials.