35304-68-8

Basic information

• Product Name: 2-Thiophenemethanol, a-(trifluoromethyl)-
• Synonyms: 2,2,2-Trifluoro-1-(thiophen-2-yl)ethan-1-ol;2-Thiophenemethanol, a-(trifluoromethyl)-;2,2,2-trifluoro-1-(thiophen-2-yl)ethanol;alpha-(Trifluoromethyl)-2-thiophenemethanol
• CAS NO: 35304-68-8
• Molecular Formula: C6H5F3OS
• Molecular Weight: 182.165
• Mol File: 35304-68-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 221.891°C at 760 mmHg
• Flash Point: 87.997°C
• Appearance: /
• Density: 1.441g/cm³
• Vapor Pressure: 0.06mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.18±0.20(Predicted)
• CAS DataBase Reference: 2-Thiophenemethanol, a-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenemethanol, a-(trifluoromethyl)-(35304-68-8)
• EPA Substance Registry System: 2-Thiophenemethanol, a-(trifluoromethyl)-(35304-68-8)

Safety Data

• Hazardous Substances Data: 35304-68-8(Hazardous Substances Data)

Usage

General Description

2-Thiophenemethanol, a-(trifluoromethyl)- is a chemical compound with the molecular formula C9H7F3OS. It is a colorless liquid with a pungent odor and is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various compounds. It is also used as a reagent in organic synthesis and as a solvent in the production of pharmaceuticals. Additionally, it has potential applications in the development of new materials and as a precursor for the synthesis of biologically active molecules. Due to its versatile properties, 2-Thiophenemethanol, a-(trifluoromethyl)- is a valuable chemical in various industries and research fields.

InChI:InChI=1/C6H5F3OS/c7-6(8,9)5(10)4-2-1-3-11-4/h1-3,5,10H

Upstream product

• 188290-36-0 thiophene 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 98-03-3 thiophene-2-carbaldehyde 
• 2314-97-8 iodotrifluoromethane 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 75-46-7 trifluoromethan 
• 3437-95-4 2-Iodothiophene 
• 807329-97-1 TurboGrignard 
• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 

Downstream Products

• 1566470-24-3 (Z)-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)thiophene 
• 1566470-25-4 (E)-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)thiophene 

Relevant articles and documents

Substitution of five-membered heteroarenes and uracils with trifluoroacetaldehyde ethyl hemiacetal

A number of α-(trifluoromethyl)heteroarylmethanols 2a-c are conveniently obtained in good yields by substitution of pyrole, furan, and thiophene with trifluoroacetaldehyde ethyl hemiacetal (TFAE); 2b and 2c are formed only in the presence of a catalyst such as ZnCl2. Analogous methanols 8a and 8b are also prepared by catalytic substitution of uracils with TFAE in moderate yields.

The direct trifluoromethylsilylation and cyanosilylation of aldehydes: via an electrochemically induced intramolecular pathway

The initiator-free electrochemical trifluoromethylsilylation and cyanosilylation of aldehydes were developed in an undivided cell. A DFT study reveals that the direct cathodic activation of trimethylsilyl reagents significantly released the congestion around the 'Si' atom, allowing the Si-O bond affinity to form concerted anion intermediates with aldehydes. Thus, intramolecular -CF3 and -CN migration make the reactions much easier to carry out without initiators.

A method of manufacturing a trifluoromethyl group-containing compound

PROBLEM TO BE SOLVED: To provide a method for producing a trifluoromethyl group-containing compound useful as a synthetic intermediate for a pharmaceutical or an agricultural chemical product.SOLUTION: There is provided a method for producing a trifluoromethyl group-containing compound represented by the following general formula (2) which is obtained by reacting a carbonyl compound having a specific structure with trifluoromethane and an organic base in an organic solvent (wherein, Rrepresents a methyl group, an ethyl group, a linear, branched or cyclic alkyl group having 3 to 10 carbon atoms, a phenyl group, a substituted phenyl group, a naphthyl group, a substituted naphthyl group, an ethenyl group, a 2-phenylethenyl group, a 9-anthryl group or a hetero ring; Rrepresents a hydrogen atom, a methyl group or a phenyl group.)