35339-68-5Relevant articles and documents
Synthesis and evaluation of new 6-hydroximinosteroid analogs as cytotoxic agents
Poza, Javier,Rega, Miriam,Paz, Vanessa,Alonso, Beatriz,Rodriguez, Jaime,Salvador, Nelida,Fernandez, Antonio,Jimenez, Carlos
, p. 4722 - 4740 (2008/03/13)
Taking into account the structural requirements for cytotoxicity, several new hydroximinosteroid derivatives have been prepared and evaluated for their cytotoxic activity against A-549, H116, PSN1, and T98G cultured tumor cell lines in order to obtain further information on the potential pharmacophoric core of this type of compound. The influence of the oxygenated position in the A ring, the presence of an additional oxygenated position at C-7 and C-16, and a fluorinated position at C-5 were considered in order to study the structure-activity relationships. The results reveal the importance of oxygenated positions in the A ring (e.g., 4,5-epoxide showed an IC50 value against HCT-116 under micromolar level) for an increase in cytotoxic activity in this type of compound. Furthermore, they showed an important selectivity toward colon tumor line (HCT-116).
Sterols in Marine Invertebrates. 49. Isolation and Structure Elucidation of Eight New Polyhydroxylated Sterols from the Soft Coral Sinularia dissecta
Jagodzinska, Barbara M.,Trimmer, James S.,Fenical, William,Djerassi, Carl
, p. 1435 - 1439 (2007/10/02)
A new group of polyhydroxylated sterols - all of them possessing an 11α-hydroxy substituents of potential utility as corticosteroid intermediates - has been isolated from the soft coral Sinularia dissecta.Their general structure was deduced from spectral data (500-MHz and 360-MHz 1H and 13C NMR and MS) and their stereochemistry was determined by correlating the respective spectral data (1H and 13C NMR) with those of synthetic sterols with similar structure and known configuration.
Studies in 1α-hydroxyl derivatives of vitamin D3. I. Syntheses of 1α-hydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3
Sato,Yamauchi,Ogata,et al.
, p. 2933 - 2940 (2007/10/06)
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