353491-45-9

Basic information

• Product Name: Alloc-Phe-Thr-OtBu
• Synonyms: Alloc-Phe-Thr-OtBu
• CAS NO: 353491-45-9
• Molecular Weight: 406.479
• Mol File: 353491-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Alloc-Phe-Thr-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: Alloc-Phe-Thr-OtBu(353491-45-9)
• EPA Substance Registry System: Alloc-Phe-Thr-OtBu(353491-45-9)

Safety Data

• Hazardous Substances Data: 353491-45-9(Hazardous Substances Data)

Upstream product

• 90508-20-6 N-allyloxycarbonyl-(S)-phenylalanate 
• 69320-90-7 L-threonine tert-butyl ester hydrochloride 

Downstream Products

• 353491-46-0 Alloc-Phe-(Z)-Dhb-OtBu 

Relevant articles and documents

Structure-activity relationship of Kahalalide F synthetic analogues

Kahalalide F (KF) is a natural product currently under phase II clinical trials. Here, we report the solid phase synthesis of 132 novel analogues of kahalalide F and their in vitro activity on a panel of up to 14 cancer cell lines. The structure-activity relationship of these analogues revealed that KF is highly sensitive to backbone stereotopical modification but not to side chain size modification. These observations suggest that this compound has a defined conformational structure and also that it interacts with chiral compounds through its backbone and not through its side chains. The N-terminal aliphatic acid appears to be a hydrophobic buoy in a membrane-like environment. Moreover, significant improvement of the in vitro activity was achieved.