35357-56-3

Basic information

• Product Name: 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLATE;6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER;6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ES
• CAS NO: 35357-56-3
• Molecular Formula: C₉H₉NO₂S
• Molecular Weight: 195.24
• Mol File: 35357-56-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 345.671 °C at 760 mmHg
• Flash Point: 162.856 °C
• Appearance: /
• Density: 1.34 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.50±0.30(Predicted)
• CAS DataBase Reference: 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER(35357-56-3)
• EPA Substance Registry System: 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER(35357-56-3)

Safety Data

• Hazardous Substances Data: 35357-56-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 21, p. 215, 1984 DOI: 10.1002/jhet.5570210143Synthesis, p. 143, 1985

Upstream product

• 335030-68-7 ethyl (Z)-2-azido-3-(3-thienyl)prop-2-enoate 
• 498-62-4 3-thiophene carboxaldehyde 
• 637-81-0 ethyl-2-azidoacetate 
• 35355-52-3 ethyl 2-azido-3-(thiophen-3-yl)acrylate 

Downstream Products

• 1007387-91-8 ethyl 2-(4-chlorobenzoyl)-6H-thieno[2,3-b]pyrrole-5-carboxylate 
• 51856-25-8 6H-thieno[2,3-b]pyrrole-5-carboxylic acid 
• 332099-01-1 2-Chloro-6H-thieno[2,3-b]pyrrole-5-carboxylic acid ethyl ester 
• 250-79-3 6H-thieno[2,3-b]pyrrole 

Relevant articles and documents

Peptidylarginine deiminase inhibitor and application thereof

The invention belongs to the technical field of medicine, and particularly relates to a peptidylarginine deiminase PAD4 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salts,stereoisomers and tautomers thereof, as well as pharmaceutical compositions, pharmaceutical preparations and application thereof. X, Y, R1, R2, R3, R4, R5, R7, R8, R9, ring B and m are as defined in the specification. The compound has inhibitory effect on peptidylarginine deiminase PAD4, and can be used for treating various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma and psoriasis.

New tetracyclic compound

The invention relates to a new tetracyclic compound. The tetracyclic compound has a structure shown in the formula (III) and can be used as a bromine domain and additional terminal (BET) inhibitor. The invention further relates to synthesis and application of the compounds in disease treatment. More specifically, the invention relates to a fused heterocyclic derivative used as a BET inhibitor, a method for the preparation of these compounds, and a disease and symptom treatment method conductive to inhibition of one or more BET bromine domains.

Structural Optimizations of Thieno[3,2-b]pyrrole Derivatives for the Development of Metabolically Stable Inhibitors of Chikungunya Virus

Chikungunya virus (CHIKV) is a re-emerging vector-borne alphavirus, and there is no approved effective antiviral treatment currently available for CHIKV. We previously reported the discovery of thieno[3,2-b]pyrrole 1b that displayed good antiviral activit