35459-13-3

Basic information

• Product Name: (-)-(R)-salbutamol acetate
• Synonyms: (-)-(R)-salbutamol acetate
• CAS NO: 35459-13-3
• Molecular Weight: 299.367
• Mol File: 35459-13-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (-)-(R)-salbutamol acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(R)-salbutamol acetate(35459-13-3)
• EPA Substance Registry System: (-)-(R)-salbutamol acetate(35459-13-3)

Safety Data

• Hazardous Substances Data: 35459-13-3(Hazardous Substances Data)

Upstream product

• 1190369-12-0 n-butyl (2R)-2-hydroxy-2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-ethyl (R)-sulfoxide 
• 1067185-91-4 (R)-2,2-dimethyl-6-(oxiran-2-yl)-4H-benzo[d][1,3]dioxine 
• 18559-94-9 Salbutamol 
• 482308-26-9 2-[(1R)(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))-perhydro-2H-pyran-2-yloxymethyl]-(1R,3R)-1,3-dithiane 1,3-dioxide 
• 482308-28-1 (2R)-2-(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))-N-(tert-butyl)-2-perhydro-2H-pyran-2-yloxyacetamide 
• 482308-27-0 (2R)-2-(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))-1-ethylthio-2-perhydro-2H-pyran-2-yloxyethan-1-one 
• 482308-25-8 2-[(1R)(2,2-dimethyl(4H-benzo[3,4-e]1,3-dioxin-6-yl))hydroxymethyl]-(1R,3R)-1,3-dithiane 1,3-dioxide 
• 54030-33-0 2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-carboxaldehyde 
• 238762-31-7 (R)-2-(N-tert-butylamino)-1-(2,2-dimethyl-4H-benzo[3,4-e]1,3-dioxin-6-yl)ethanol 
• 64-19-7 acetic acid 
• 24085-03-8 α-[(benzyl-tert-butylamino)methyl]-m-xylene-4,α,α'-triol 
• 119072-55-8 tert-butylisonitrile 
• 54030-32-9 4-hydroxy-3-(hydroxymethyl)benzaldehyde 

Relevant articles and documents

Efficient Synthesis of 2-Amino-1-Arylethanols Through a Lewis Base-Catalyzed SiCl4-Mediated Asymmetric Passerini-Type Reaction

We herein report, a practical and efficient strategy for the synthesis of enantiomerically enriched 2-amino-1-arylethanols, a structural motif commonly encountered in the family of β-adrenergic blockers or agonists, through a Lewis base-catalyzed SiClsub

One-pot synthesis of N-substituted β-amino alcohols from aldehydes and isocyanides

A practical two-stage one-pot synthesis of N-substituted β-amino alcohols using aldehydes and isocyanides as starting materials has been developed. This method features mild reaction conditions, broad scope, and general tolerance of functional groups. Based on a less common central carbon-carbon bond disconnection, this protocol complements traditional approaches that involve amines and various carbon electrophiles (epoxides, α-halo ketones, β-halohydrins). Medicinally relevant products can be prepared in a concise and efficient way from simple building blocks, as demonstrated in the synthesis of the antiasthma drug salbutamol. Upgrading the synthesis to an enantioselective variant is also feasible.

Application of the chiral acyl anion equivalent, trans-1,3-dithiane 1,3-dioxide, to an asymmetric synthesis of (R)-salbutamol

An enantioselective synthesis of (R)-salbutamol has been carried out using the chiral, C2 symmetric acyl anion equivalent, (1R,3R)-1,3-dithiane 1,3-dioxide, which undergoes addition to an aromatic aldehyde with very high stereocontrol at 0 °C. Pummerer reaction and work-up with lithium ethanethiolate generated the α-hydroxy thiolester in high yield and further transformations led to the target compound with high enantiomeric excess.