35856-62-3

Basic information

• Product Name: PIPERIDINE-1-SULFONYL CHLORIDE
• Synonyms: piperidine-1-sulfonyl chloride(SALTDATA: FREE);Piperadine-1-sulfonylchloride;N-piperidinylsulfaMoyl chloride;1-Piperidinesulfonylchloride;Piperidinesulfonyl chloride;Piperidinosulfonyl chloride;Piperidine-1-sulfonyl chloride 96%
• CAS NO: 35856-62-3
• Molecular Formula: C₅H₁₀ClNO₂S
• Molecular Weight: 183.66
• Mol File: 35856-62-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 120℃ (10 Torr)
• Flash Point: 119.6°C
• Appearance: /
• Density: 1.308 g/mL at 25 °C
• Vapor Pressure: 0.00547mmHg at 25°C
• Refractive Index: 1.4920
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -8.25±0.20(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: PIPERIDINE-1-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERIDINE-1-SULFONYL CHLORIDE(35856-62-3)
• EPA Substance Registry System: PIPERIDINE-1-SULFONYL CHLORIDE(35856-62-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8 / PGII
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅱ
• Hazardous Substances Data: 35856-62-3(Hazardous Substances Data)

Usage

Uses

Piperidine-1-sulfonyl chloride is used as pharmaceutical intermediate.

InChI:InChI=1/C5H10ClNO2S/c6-10(8,9)7-4-2-1-3-5-7/h1-5H2

Upstream product

• 110-89-4 piperidine 
• 16475-29-9 phenylchlorosulfate 
• 2156-71-0 N-chloropiperidine 
• 6091-44-7 piperidine hydrochloride 
• 110-85-0 piperazine 

Downstream Products

• 105168-75-0 N-[2-Chloro-4-(piperidine-1-sulfonylamino)-phenyl]-acetamide 
• 105168-60-3 N-[2-Methyl-4-(piperidine-1-sulfonylamino)-phenyl]-acetamide 
• 105168-51-2 Piperidine-1-sulfonic acid (2-methyl-4-nitro-phenyl)-amide 
• 105168-40-9 Piperidine-1-sulfonic acid (4-amino-3-nitro-phenyl)-amide 
• 90233-68-4 N-Phenyl-3-(piperidine-1-sulfonylamino)-benzamide 
• 76495-39-1 5,6,7,8-Tetrahydro-2-methyl-4-(piperidinosulfonyloxy)chinolin 
• 124104-58-1 2-[tert-butoxycarbonyl-(piperidine-1-sulfonylamino)-methyl]-5,5-dimethyl-thiazolidine-4-carboxylic acid benzyl ester 
• 1020-49-1 N-(phenoxysulfonyl)-piperidine 
• 100391-95-5 piperidine-1-sulfonic acid-(4-formyl-phenyl ester) 
• 4703-22-4 N-tosylpiperidine 

Relevant articles and documents

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Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors

p53-MDM2/MDMX interaction inhibitors represent the prospective agents for targeted anticancer therapy in tumors expressing wild-type p53 protein. Imidazoline-based MDM2-targeted inhibitors of such type, nutlins, contain halogen-substituted phenyl rings, w

S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling

Sulfuric chloride is used as the source of the -SO2- group in a palladium-catalyzed three-component synthesis of sulfonamides. Suzuki-Miyaura coupling between the in situ generated sulfamoyl chlorides and boronic acids gives rise to diverse sulfonamides in moderate to high yields with excellent reaction selectivity. Although this transformation is not workable for primary amines or anilines, the results show high functional group tolerance. With the solving of the desulfonylation problem and utilization of cheap and easily accessible sulfuric chloride as the source of sulfur dioxide, redox-neutral three-component synthesis of sulfonamides is first achieved. This journal is

PREPARATION OF COBICISTAT INTERMEDIATES

The present disclosure provides crystalline piperidine sulfamoyl intermediates of formula 8 and 9. The present disclosure also relates to an improved process for the preparation of cobicistat using compounds of formulae 8 and 9.