358780-13-9

Basic information

• Product Name: 6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE
• Synonyms: 6-(Trifluoromethyl)pyridine-3-carbonyl chloride 97%;6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE;6-(TRIFLUOROMETHYL)NICOTINYL CHLORIDE;3-Pyridinecarbonyl chloride, 6-(trifluoromethyl)- (9CI);6-(TRIFLUOROMETHYL)NICOTINOYLCHLORIDEUNNUMBER3265,CLASS8,PACKINGGROUP3 ;6-(Trifluoromethyl)nicotinoyl chloride 98%;6-(Trifluoromethyl)nicotinoylchloride98%;6-(Trifluoromethyl)pyridine-3-carbonyl chloride
• CAS NO: 358780-13-9
• Molecular Formula: C₇H₃ClF₃NO
• Molecular Weight: 209.55
• EINECS: 206-621-5
• Product Categories: Heterocyclic Building Blocks;ACIDHALIDE;Heterocycles;C7 and C8;Heterocyclic Building Blocks;Pyridines;Building Blocks;C6 to C7;Chemical Synthesis
• Mol File: 358780-13-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 54 °C2 mm Hg(lit.)
• Flash Point: 228 °F
• Appearance: /
• Density: 1.438 g/mL at 25 °C(lit.)
• Vapor Pressure: 18.1mmHg at 25°C
• Refractive Index: n20/D 1.4750(lit.)
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE(358780-13-9)
• EPA Substance Registry System: 6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE(358780-13-9)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 358780-13-9(Hazardous Substances Data)

Usage

General Description

6-(Trifluoromethyl)nicotinoyl chloride is an organohalide compound with the chemical formula C7H3ClF3NO. It is a chlorinated derivative of nicotinic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is a white to light yellow solid that is soluble in polar solvents such as ethanol and acetone. It is a highly reactive compound and is typically handled and stored under inert gas to prevent decomposition. 6-(Trifluoromethyl)nicotinoyl chloride is known for its ability to introduce the trifluoromethyl group into various organic compounds, making it a valuable building block in organic synthesis.

InChI:InChI=1/C2H3Br2F/c3-1-2(4)5/h2H,1H2

Upstream product

• 79-37-8 oxalyl dichloride 
• 231291-22-8 6-trifluoromethylnicotinic acid 

Downstream Products

• 868209-73-8 N-(4-chlorophenyl)-N-((2S,4R)-2-methyl-1-{[6-(trifluoromethyl)pyridin-3-yl]carbonyl}-1,2,3,4-tetrahydroquinolin-4-yl)acetamide 
• 416852-53-4 N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide 
• 953091-57-1 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester 
• 948551-74-4 5-isocyanato-2-(trifluoromethyl)pyridine 
• 358780-14-0 1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one 
• 1015078-44-0 3-dimethylamino-1-(6-trifluoromethylpyridin-3-yl)-propenone 
• 869794-18-3 [(6R,9aS)-6-(4-hydroxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-2-yl]-(6-trifluoromethyl-pyridin-3-yl)-methanone 

Relevant articles and documents

3-Substituted Quinolines as RORγt Inverse Agonists

We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but are high molecular weight and they exhibited poor solubility at pH 2 and pH 7. This manuscript details our efforts at improving physical chemical properties for this series of compounds by increasing the diversity at the 3-position (i.e. introducing heteroatoms and lowering the molecular weight). These efforts have led to molecules which are potent binders with improved solubility.

Nickel-Catalyzed Addition of C–C Bonds of Amides to Strained Alkenes: The 1,2-Carboaminocarbonylation Reaction

C(aryl)–C(═O) bonds of aryl amides can be activated and added across alkenes with the aid of a nickel catalyst. This 1,2-carboaminocarbonylation reaction enables the dicarbofunctionalization of alkenes with an atom economy of 100%.

Novel Inhibitors of an Insect Pest Chitinase: Design and Optimization of 9-O-Aromatic and Heterocyclic Esters of Berberine

OfChi-h, a lepidopteran-exclusive glycoside hydrolase family 18 (GH18) chitinase from the agricultural insect pest Ostrinia furnacalis, is a promising molecular target candidate for pest control and management. Berberine (BER), a traditional Chinese medic