953091-57-1

Basic information

• Product Name: 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester
• Synonyms: 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester
• CAS NO: 953091-57-1
• Molecular Weight: 453.458
• Mol File: 953091-57-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester(953091-57-1)
• EPA Substance Registry System: 6-trifluoromethylnicotinic acid 5-tert-butoxycarbonylmethoxy-2-tert-butylphenyl ester(953091-57-1)

Safety Data

• Hazardous Substances Data: 953091-57-1(Hazardous Substances Data)

Upstream product

• 358780-13-9 6-(trifluoromethyl)nicotinoyl chloride 
• 953091-49-1 (4-tert-butyl-3-hydroxy-phenoxy)acetic acid tert-butyl ester 

Downstream Products

• 953091-58-2 6-trifluoromethyl-nicotinic acid 2-tert-butyl-5-carboxymethoxyphenyl ester 

Relevant articles and documents

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, inflammatory disease of the joints, neuropathies, HIV-related neuropathy, nerve injury, neurodegeneration, stroke, urinary bladder hypersensitivity including urinary incontinence, cystitis, stomach duodenal ulcer, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), fecal urgency, gastro-esophageal reflux disease (GERD), Crohn's disease, asthma, chronic obstructive pulmonary disease, cough, neurotic/allergic/inflammatory skin disease, psoriasis, pruritus, prurigo, irritation of skin, eye or mucous membrane, hyperacusis, tinnitus, vestibular hypersensitivity, episodic vertigo, cardiac diseases such as myocardial ischemia, hair growth-related disorders such as effluvium, alopecia, rhinitis, and pancreatitis.