3592-81-2

Basic information

• Product Name: N-cyclohexyl-N-propylamine
• Synonyms: N-cyclohexyl-N-propylamine;N-propylcyclohexanamine;UKRORGSYN-BB BBV-060551;cyclohexyl(propyl)amine;N-propylcyclohexanamine(SALTDATA: FREE)
• CAS NO: 3592-81-2
• Molecular Formula: C₉H₁₉N
• Molecular Weight: 141.26
• Mol File: 3592-81-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 191.3°Cat760mmHg
• Flash Point: 59.5°C
• Appearance: /
• Density: 0.84g/cm³
• Vapor Pressure: 0.517mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-cyclohexyl-N-propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-N-propylamine(3592-81-2)
• EPA Substance Registry System: N-cyclohexyl-N-propylamine(3592-81-2)

Safety Data

• Hazardous Substances Data: 3592-81-2(Hazardous Substances Data)

Usage

General Description

N-cyclohexyl-N-propylamine is a chemical compound with the molecular formula C9H19N. It is an organic compound belonging to the amine family, and it is commonly used as a solvent and intermediate in chemical synthesis. This chemical is a colorless liquid with a faint amine odor, and it is insoluble in water, but soluble in organic solvents. N-cyclohexyl-N-propylamine is considered to have low toxicity, with no known carcinogenic or mutagenic properties. It is commonly used in the manufacturing of pharmaceuticals, pesticides, and rubber chemicals, as well as in the production of surfactants and corrosion inhibitors. Additionally, it is utilized as a stabilizer in the production of polyurethane foams and adhesives.

InChI:InChI=1/C9H19N/c1-2-8-10-9-6-4-3-5-7-9/h9-10H,2-8H2,1H3

Upstream product

• 108-94-1 cyclohexanone 
• 107-12-0 propiononitrile 
• 107-10-8 propylamine 
• 71-23-8 propan-1-ol 
• 108-91-8 cyclohexylamine 
• 98-95-3 nitrobenzene 
• 100-60-7 N-methylcyclohexylamine 
• 74-85-1 ethene 
• 110-82-7 cyclohexane 
• 1821-39-2 2-propylaniline 
• 108-03-2 1-Nitropropane 
• 22668-89-9 N-(cyclohexylidene)-1-propanamine 
• 1126-56-3 N-cyclohexylpropanamide 
• 620-71-3 N-(phenyl)-2-methylacetamide 

Downstream Products

• 69592-75-2 N-Cyclohexyl-4-(2-oxo-1,2-dihydro-quinolin-6-yloxy)-N-propyl-butyramide 
• 99175-78-7 N-cyclohexyl-N-propyl-formamide 
• 1114590-89-4 N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclohexyl(propyl)amino]pyrimidine-4-carboxamide 
• 1174409-94-9 C₂₂H₃₄N₂O₃ 
• 46711-23-3 <2-(Cyclohexyl-propyl-amino)-aethyl>-guanidin 
• 83604-88-0 2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-cyclohexyl-N-propyl-propionamide 
• 141312-52-9 N-Cyclohexyl-2-phenyl-N-propyl-acetamide 
• 83605-19-0 N-Cyclohexyl-N-propyl-propionamide 
• 1195-49-9 N-cyclohexylpropionaldimine 
• 64090-64-8 3-(2-Methoxy-aethoxycarbonyl-amino)-phenyl-N-cyclohexyl-N-propyl-carbamat 
• 64796-97-0 3-[1-(4-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-propyl-urea 
• 64796-73-2 3-[1-(3-Chloro-phenyl)-1-methyl-ethyl]-1-cyclohexyl-1-propyl-urea 
• 57375-67-4 N-Isopropoxycarbonyl-3-(N-cyclohexyl-N-propylcarbamoyloxy)anilin 
• 52702-96-2 2,6-Dibromo-4-[(cyclohexyl-propyl-amino)-methyl]-phenol 

Relevant articles and documents

Titanium-Catalyzed Hydroaminoalkylation of Ethylene

The first examples of titanium-catalyzed hydroaminoalkylation reactions of ethylene with secondary amines are presented. The reactions can be achieved with various titanium catalysts and they do not require the use of high pressure equipment. In addition, the first solid-state structure of a titanapyrrolidine that is formed by insertion of an alkene into the Ti?C bond of a titanaaziridine is reported.

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space-time yield of 2 g L-1 d-1.

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

Imine reductases (IREDs) show great potential as catalysts for reductive amination of ketones to produce chiral secondary amines. In this work, we explored this potential and synthesized the pharmaceutically relevant (R)-rasagiline in high yields (up to 81%) and good enantiomeric excess (up to 90% ee) from the ketone precursor. This one-step approach in aqueous medium represents the shortest synthesis route from achiral starting materials. Furthermore, we demonstrate for the first time that tertiary amines also can be accessed by this route, which provides new opportunities for eco-friendly enzymatic asymmetric syntheses of these important molecules.