35999-20-3

Basic information

• Product Name: 3-Chloro-1-(4-methoxyphenyl)propan-1-one
• Synonyms: BETA-CHLORO-4-METHOXYPROPIOPHENONE;3'-CHLORO-4-METHOXY PROPIOPHENONE;3-CHLORO-4'-METHOXY PROPIOPHENONE;3-CHLORO-1-(4-METHOXYPHENYL)-1-OXOPROPANE;4'-Methoxy-3-chloropropiophenone;alpha-chloro-4-methoxypropiophenone;-Chloro-4-methoxypropiophenone;2-CHLORO-4'-METHOXYPROPIOPHENONE
• CAS NO: 35999-20-3
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• Mol File: 35999-20-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 61.0 to 65.0 °C
• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 143.7 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-Chloro-1-(4-methoxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-1-(4-methoxyphenyl)propan-1-one(35999-20-3)
• EPA Substance Registry System: 3-Chloro-1-(4-methoxyphenyl)propan-1-one(35999-20-3)

Safety Data

• Hazardous Substances Data: 35999-20-3(Hazardous Substances Data)

Usage

Description

3-Chloro-1-(4-methoxyphenyl)propan-1-one is an organic compound with the molecular formula C10H11ClO2. It is characterized by the presence of a chloro group attached to the third carbon atom of a propanone structure, with a 4-methoxyphenyl group attached to the first carbon. 3-Chloro-1-(4-methoxyphenyl)propan-1-one has potential applications in the pharmaceutical and chemical industries due to its unique structural features and biological activities.

Uses

Used in Pharmaceutical Industry:
3-Chloro-1-(4-methoxyphenyl)propan-1-one is used as a potent PARP-1 inhibitor for its ability to inhibit the activity of the enzyme poly(ADP-ribose) polymerase 1 (PARP-1). This inhibition plays a crucial role in the development of antitumor agents, as PARP-1 is involved in DNA repair mechanisms that can contribute to the survival of cancer cells. By targeting PARP-1, this compound can potentially enhance the effectiveness of cancer treatments and improve patient outcomes.
Additionally, 3-Chloro-1-(4-methoxyphenyl)propan-1-one can be used as an antitumor agent due to its direct effects on cancer cells. Its chemical structure allows it to interact with cellular targets, disrupting essential processes within the cancer cells and leading to their death. This dual action as both a PARP-1 inhibitor and an antitumor agent makes it a valuable compound for further research and development in the fight against cancer.
Used in Chemical Industry:
In the chemical industry, 3-Chloro-1-(4-methoxyphenyl)propan-1-one may also find applications as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structural features, including the chloro and methoxyphenyl groups, can be further modified or used as starting points for the development of new compounds with diverse applications.

InChI:InChI=1/C10H11ClO2/c1-13-9-4-2-8(3-5-9)10(12)6-7-11/h2-5H,6-7H2,1H3

Upstream product

• 107-94-8 chloropropionic acid 
• 100-66-3 methoxybenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 5770-77-4 1-(4-methoxyphenyl)-3-morpholinopropan-1-one 
• 3708-28-9 2-(3-(4-methoxyphenyl)-3-oxopropyl)isoindoline-1,3-dione 
• 94673-95-7 2-[3-(4-methoxy-phenyl)-3-oxo-propyl]-1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one 
• 132427-82-8 3-[(7-Isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-ylmethyl)-amino]-1-(4-methoxy-phenyl)-propan-1-one 
• 97802-15-8 4-p-bromophenyl-7-p-methoxyphenyl-1,10-phenanthroline 
• 92868-60-5 4-(4'-methoxyphenyl)-8-nitroquinoline 
• 68689-99-6 8-Ethyl-2-{4-[3-(4-methoxy-phenyl)-3-oxo-propyl]-piperazin-1-yl}-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 56475-33-3 3-methoxy-1-(4-methoxyphenyl)propan-1-one 
• 98013-08-2 cyclohexane-1,3,5-triyltris((4-methoxyphenyl)methanone) 
• 345949-40-8 (R)-3-chloro-1-(4'-methoxyphenyl)propan-1-ol 
• 57012-41-6 2-Methyl-2-<3-(p-methoxyphenyl)-5-methoxy-pent-2-enyl>-cyclopentan-1,3-dion 
• 57012-40-5 2-Methyl-2-<3-(p-methoxyphenyl)-5-methoxy-pent-2-enyl>-cyclopentan-1,3-dion 
• 56475-36-6 2-[5-Methoxy-3-(4-methoxy-phenyl)-pentyl]-2-methyl-cyclopentane-1,3-dione 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 

Relevant articles and documents

Metabolically stable vanillin derivatives for the treatment of hypoxia

Vanillin derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.

An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s

Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress

Excess lipid accumulation can initiate the development and progression of atherosclerotic lesions, thus eventually leading to cardiovascular disease. Lipid-lowering medication therapy is one of the cornerstones of cardiovascular disease therapy. On the basis of the cholesterol absorption inhibitor ezetimibe, we successfully synthesized seven 2-azetidinone derivatives and eighteen 1H-pyrrole-2,5-dione derivatives. Most of the new compounds significantly inhibited cholesterol uptake in vitro. In addition, one of the most active inhibitors, 3-(4-fluorophenyl)-1-[(3S)-3-hydroxy-3-(4-hydroxyphenyl)propyl]-4-(4-hydroxyphenyl)-1H-pyrrole-2,5-dione (14q), showed no cytotoxicity in L02 and HEK293T cell lines. Further evaluation indicated that 14q inhibited considerably the amount of TNF-α, ROS, MDA, and LDH in vitro. Therefore, 14q might be a novel cholesterol absorption inhibitor.