36192-63-9

Basic information

• Product Name: 2-AMINO-4'-METHYLBENZOPHENONE
• Synonyms: 2-AMINO-4'-METHYLBENZOPHENONE;TIMTEC-BB SBB005854;2-amino-4'-methylbenzophenone m;2-AMINO-4-METHYLBENZOPHENONE 99%;2-Amino-4'-methylbenzophenone,99%;(2-AMinophenyl)(p-tolyl)Methanone
• CAS NO: 36192-63-9
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• EINECS: 252-905-7
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 36192-63-9.mol
• Article Data: 36

Chemical Properties

• Melting Point: 91 °C
• Boiling Point: 350.95°C (rough estimate)
• Flash Point: 200°C
• Appearance: Yellow/Fine Crystalline Powder
• Density: 1.0694 (rough estimate)
• Refractive Index: 1.5780 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-AMINO-4'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4'-METHYLBENZOPHENONE(36192-63-9)
• EPA Substance Registry System: 2-AMINO-4'-METHYLBENZOPHENONE(36192-63-9)

Safety Data

• Hazardous Substances Data: 36192-63-9(Hazardous Substances Data)

Usage

Description

2-AMINO-4'-METHYLBENZOPHENONE is an organic compound with the chemical formula C14H13NO. It is a yellow fine crystalline powder known for its role in the palladium-catalyzed preparation and antitumor activity of various compounds, including 2-aminobenzophenones, benzoyloxoindolines, and 7-benzoylindoles.

Uses

Used in Pharmaceutical Industry:
2-AMINO-4'-METHYLBENZOPHENONE is used as an intermediate in the synthesis of various pharmaceutical compounds for its palladium-catalyzed preparation and antitumor activity. It plays a crucial role in the development of new drugs targeting cancer treatment.
Used in Chemical Research:
2-AMINO-4'-METHYLBENZOPHENONE is used as a research compound in the field of organic chemistry, particularly for studying the synthesis and properties of related benzophenone derivatives and their potential applications in various industries.
Used in Antitumor Applications:
2-AMINO-4'-METHYLBENZOPHENONE is used as a key component in the development of antitumor agents, contributing to the palladium-catalyzed preparation of compounds with potential cancer-fighting properties. Its involvement in the synthesis of 2-aminobenzophenones, benzoyloxoindolines, and 7-benzoylindoles highlights its importance in the search for novel and effective cancer treatments.

Upstream product

• 71319-20-5 (4-methylphenyl)(2-nitrophenyl)methanone 
• 37892-50-5 3-(4-methylphenyl)benzo[c]isoxazole 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 624-31-7 4-tolyl iodide 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 108-88-3 toluene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 1885-29-6 anthranilic acid nitrile 
• 34999-55-8 (2-aminophenyl)(p-tolyl)methanol 
• 201230-82-2 carbon monoxide 
• 615-43-0 2-iodophenylamine 
• 5720-05-8 4-methylphenylboronic acid 
• 941-55-9 4-toluenesulfonyl azide 
• 134-84-9 4-Methylbenzophenone 

Downstream Products

• 113802-22-5 3-Aziridin-1-ylmethyl-4-p-tolyl-quinolin-2-ylamine 
• 113802-27-0 3-Piperidin-1-ylmethyl-4-p-tolyl-quinolin-2-ylamine 
• 85422-46-4 9-(4-Methylphenyl)furo<3,4-b>quinolin-1(3H)-one 
• 91888-73-2 2-(4-p-Tolyl-quinolin-2-yl)-quinoxaline 
• 102998-11-8 (4-Hydroxy-4-p-tolyl-4H-benzo[d][1,2,3]triazin-3-yl)-acetonitrile 
• 98369-72-3 3-Dimethylaminomethyl-4-p-tolyl-quinolin-2-ylamine 
• 106537-12-6 (2-{[1-(2-Amino-5-chloro-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-phenyl)-p-tolyl-methanone 
• 71526-50-6 6-Chloro-4,4-diphenyl-1,2-dihydro-3,1-benzoxazin-2(4H)-one 
• 34999-55-8 (2-aminophenyl)(p-tolyl)methanol 
• 313398-24-2 3-acetyl-4-(4-methylphenyl)-1,2-dihydroquinolin-2-one 
• 149323-56-8 4-(4-methylphenyl)-3-quinolinecarboxylate 
• 174399-51-0 2-bromo-N-[2-(4-methyl-benzoyl)-phenyl]-acetamide 
• 37892-50-5 3-(4-methylphenyl)benzo[c]isoxazole 
• 1025506-21-1 4-(4-methylphenyl)-2,1,3-benzothiadiazine 2,2-dioxide 

Relevant articles and documents

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

Gold-catalyzed cyclization of 1-(2′-Azidoaryl) propynols: Synthesis of polysubstituted 4-quinolones

An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones from 1-(2′-Azidoaryl) propynols is described. The reaction undergoes an intramolecular nucleophilic attack of the azide group to the Au-Activated triple bonds in a 6-endo-dig manner and subsequent gold-Assisted expulsion of N2 to furnish an α-imino gold carbene intermediate, which triggers a 1,2-carbon migration and finally is converted to 2,3-disubstituted 4-quinolone.

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.