3620-18-6

Basic information

• Product Name: 3-acetyldihydro-5-methylfuran-2(3H)-one
• Synonyms: 3-Acetyl-5-methyl-4,5-dihydro-2(3H)-furanone;3-Acetyldihydro-5-methyl-2(3H)-furanone;5-Methyl-3-acetyl-4,5-dihydrofuran-2(3H)-one;Einecs 222-816-8;2(3H)-Furanone, 3-acetyldihydro-5-Methyl-;3-acetyldihydro-5-methylfuran-2(3H)-one
• CAS NO: 3620-18-6
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.1525
• EINECS: 222-816-8
• Mol File: 3620-18-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 281.5 °C at 760 mmHg
• Flash Point: 124.4 °C
• Appearance: /
• Density: 1.114 g/cm³
• Vapor Pressure: 0.00355mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: 3-acetyldihydro-5-methylfuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyldihydro-5-methylfuran-2(3H)-one(3620-18-6)
• EPA Substance Registry System: 3-acetyldihydro-5-methylfuran-2(3H)-one(3620-18-6)

Safety Data

• Hazardous Substances Data: 3620-18-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 4368, 1950 DOI: 10.1021/ja01166a010

InChI:InChI=1/C7H10O3/c1-4-3-6(5(2)8)7(9)10-4/h4,6H,3H2,1-2H3

Upstream product

• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 75-56-9 methyloxirane 
• 64-17-5 ethanol 
• 141-97-9 ethyl acetoacetate 
• 75-21-8 oxirane 
• 105-45-3 acetoacetic acid methyl ester 
• 16088-62-3 (S)-Propylene oxide 
• 15448-47-2 (R)-propylene oxide 

Downstream Products

• 589-93-5 2,5-dimethylpyridine 
• 75337-05-2 4-methyl-2-cyclohexenone 
• 4316-49-8 exogonic acid 
• 104723-24-2 5-diphenylphosphinoyl-6-hydroxy-5-methyl-6-phenylhexan-2-one ethylene acetal 
• 104723-24-2 5-diphenylphosphinoyl-6-hydroxy-5-methyl-6-phenylhexan-2-one ethylene acetal 
• 104723-21-9 5-diphenylphosphinoylhexan-2-one ethylene acetal 
• 62052-89-5 8-(4-methoxy-benzyl)-5,7-dimethyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine 
• 62052-90-8 8-(2-chloro-benzyl)-5,7-dimethyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine 
• 62052-91-9 8-(2-fluoro-benzyl)-5,7-dimethyl-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine 
• 488-10-8 cis-jasmone 
• 1128-08-1 dihydro-cis-jasmone 
• 7018-92-0 2,5-Undecanedione 
• 403611-08-5 5-trans-(2-methylcyclopropyl)hex-1-en-5-yne 
• 95046-97-2 5-methyl-dihydro-furan-2,3-dione-3-phenylhydrazone 

Relevant articles and documents

Process for the preparation of butyrolactones

The present invention relates to a process for the preparation of γ-butyrolactones.

A highly efficient synthetic route to (-)-furaquinocin C

The first total synthesis of (-)-furaquinocin C, a member of the furaquinocin family of cytotoxic antibiotics, has been achieved. Central features of the successful synthetic strategy include Dieis-Alder construction of the furanonaphthoquinic skeleton and sequential cuprate- mediated conjugate additions to an α,β-unsaturated lactone. The synthetic route proved remarkably efficient requiting only six steps from (R)-(+)- angelicalactone, and utilizing a mere four reaction vessels. This stereospecific construction of (-)-furaquinocin C confirms earlier assignments of absolute and relative stereochemistry for the furaquinocins and also constitutes completion of a formal synthesis of (-)-furaquinocin F.

Improved process for the preparation of substituted furanones

This invention relates to an improved process for the preparation of 3-acyl-5-alkyldihydro-2(3H)-furanones according to the following reaction scheme: wherein R and R1 are hydrogen or alkyl and R2 is a hydrocarbon or -0-hydrocarbon radical of from 1 to 20 carbon atoms and X is a leaving group.