363599-64-8

Basic information

• Product Name: (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester
• CAS NO: 363599-64-8
• Molecular Weight: 550.652
• Mol File: 363599-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester(363599-64-8)
• EPA Substance Registry System: (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester(363599-64-8)

Safety Data

• Hazardous Substances Data: 363599-64-8(Hazardous Substances Data)

Upstream product

• 153080-83-2 ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate 
• 4392-24-9 Cinnamyl bromide 
• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 

Downstream Products

• 363599-67-1 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-hydroxy-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-68-2 (3R,6S,8R,8aR)-3-tert-Butoxycarbonylamino-4-oxo-8-(3-phenyl-propyl)-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carboxylic acid ethyl ester 
• 363599-65-9 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-oxo-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

A convenient and versatile synthesis of 6,5- and 7,5-fused bicyclic lactams as peptidomimetics

Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH2Cl2 generated an N-ac