153080-83-2

Basic information

• Product Name: ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate
• Synonyms: ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate
• CAS NO: 153080-83-2
• Molecular Weight: 373.449
• Mol File: 153080-83-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate(153080-83-2)
• EPA Substance Registry System: ethyl (2S,4R,E)-N-BOC-4-cinnamylpyroglutamate(153080-83-2)

Safety Data

• Hazardous Substances Data: 153080-83-2(Hazardous Substances Data)

Upstream product

• 144978-35-8 (S)-ethyl N-tert-butoxycarbonylpyroglutamate 
• 4392-24-9 Cinnamyl bromide 

Downstream Products

• 284024-88-0 ethyl (2S,4R)-N-Boc-4-(3-phenylpropyl)pyroglutamate 
• 363599-66-0 (2S,4R)-5-Oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-68-2 (3R,6S,8R,8aR)-3-tert-Butoxycarbonylamino-4-oxo-8-(3-phenyl-propyl)-hexahydro-pyrrolo[2,1-b][1,3]oxazine-6-carboxylic acid ethyl ester 
• 363599-65-9 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-oxo-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-67-1 (2S,4R)-1-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propionyl)-5-hydroxy-4-(3-phenyl-propyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 363599-64-8 (2S,4R)-1-((R)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionyl)-5-oxo-4-((E)-3-phenyl-allyl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

A convenient and versatile synthesis of 6,5- and 7,5-fused bicyclic lactams as peptidomimetics

Chemo-selective reduction of the pyroglutamate ring carbonyl in a serine-pyroglutamate or homoserine to pyroglutamate dipeptide gave a hemiaminal. Treatment of the hemiaminal with a catalytic amount of TFA in CH2Cl2 generated an N-ac