364794-58-1

Basic information

• Product Name: 5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine
• Synonyms: 364794-58-1; 5-Bromo-2-(4-methyl-piperazin-1-yl)pyridine5-Bromo-2-(4-Boc-Piperazin-1-Yl)Pyridine
• CAS NO: 364794-58-1
• Molecular Formula: C10H14BrN3
• Molecular Weight: 256.15
• EINECS: 200-589-5
• Product Categories: pharmacetical;Organohalides;Pyridine
• Mol File: 364794-58-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 341.2°C at 760 mmHg
• Flash Point: 160.1°C
• Appearance: /
• Density: 1.406g/cm³
• Vapor Pressure: 8.18E-05mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.12±0.42(Predicted)
• CAS DataBase Reference: 5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine(364794-58-1)
• EPA Substance Registry System: 5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine(364794-58-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 364794-58-1(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine is a chemical compound often used in the field of organic synthesis and pharmaceutical drug development. The term 'Boc' in the name refers to the tertiary butyloxycarbonyl group, a commonly used protecting group for amines in organic synthesis. It's a compound that includes a bromine atom and a pyridine ring, which is a six-member ring compound containing five carbon atoms and one nitrogen atom. 5-Bromo-2-(4-Boc-piperazin-1-yl)pyridine is often used as a reagent or building block in larger, more complex molecules, due to its reactivity and versatility.

InChI:InChI=1/C10H14BrN3/c1-13-4-6-14(7-5-13)10-3-2-9(11)8-12-10/h2-3,8H,4-7H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 766-11-0 5-bromo-2-fluoropyridine 
• 624-28-2 2,5-dibromopyridine 
• 53939-30-3 5-bromo-2-chloropyridine 

Downstream Products

• 918524-63-7 1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine 
• 1416000-00-4 2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one 
• 1426259-53-1 6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine 
• 1426259-67-7 N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}thiazol-2-yl)cyclopropanecarboxamide 

Relevant articles and documents

TETRAHYDROBENZOFURO[2,3-C]PYRIDINE AND BETA-CARBOLINE COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES

The present invention relates to novel compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).

Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines

A new catalyst system capable of selective chloride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported. A reaction optimization strategy employing ligand parametrization led to the identification of 1,1′-bis[bis(dimethylamino)phosphino]ferrocene "DMAPF", a readily available yet previously unutilized diphosphine, as a uniquely effective ligand for this transformation.

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design

The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment screening hit scaffold using structure guided design. These inhibitors show potent Gram-positive antibacterial activity and low resistance incidence against clinically important pathogens.