3663-34-1

Basic information

• Product Name: N-(4-ethylphenyl)acetamide
• Synonyms: N-(4-ethylphenyl)acetamide
• CAS NO: 3663-34-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: -0
• Mol File: 3663-34-1.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 189.8°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: N-(4-ethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-ethylphenyl)acetamide(3663-34-1)
• EPA Substance Registry System: N-(4-ethylphenyl)acetamide(3663-34-1)

Safety Data

• Hazardous Substances Data: 3663-34-1(Hazardous Substances Data)

Usage

General Description

N-(4-ethylphenyl)acetamide, also known as 4-ethylacetanilide, is an organic compound with the chemical formula C10H13NO. It is a derivative of acetanilide and is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and pesticides. N-(4-ethylphenyl)acetamide is a white solid at room temperature and is soluble in most organic solvents. N-(4-ethylphenyl)acetamide is primarily used as a precursor in the production of various pharmaceutical drugs, particularly analgesics and antipyretics. It is also employed in the synthesis of herbicides and other agricultural chemicals. Due to its versatile applications, this chemical is an important building block in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H13NO/c1-3-9-4-6-10(7-5-9)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

Upstream product

• 529-65-7 N-ethylacetanilide 
• 108-24-7 acetic anhydride 
• 589-16-2 4-aminoethylbenzene 
• 7664-93-9 sulfuric acid 
• 2089-32-9 1-(p-ethylphenyl)ethanone oxime 
• 52436-73-4 4-ethylbenzenediazonium tetrafluoroborate 
• 75-05-8 acetonitrile 
• 1220120-57-9 tert-butyl N-(p-ethylphenyl)carbamate 
• 75-36-5 acetyl chloride 
• 74-96-4 ethyl bromide 
• 103-84-4 Acetanilid 
• 75-00-3 chloroethane 
• 5396-89-4 benzyl acetoacetate 
• 4218-48-8 1-ethyl-4-isopropylbenzene 

Downstream Products

• 3663-35-2 4-ethyl-2-nitroaniline 
• 1401456-88-9 2-acetylamino-5-ethylbenzoic acid ethyl ester 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 338428-47-0 6-ethyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde 
• 53498-47-8 N-(4-vinyl-phenyl)-acetamide 
• 436088-07-2 2-chloro-6-ethyl-3-formylquinoline 

Relevant articles and documents

Determination of Alkyl Anilines and Alkyl Pyridines in Solvent Refined Coal Distillates and Aqueous Extracts by Gas Chromatography/Mass Spectrometry

Derivatization with acetic anhydride in aqueous media coupled with capillary gas chromatography/mass spectrometry was used to distinguish alkyl anilines from alkyl pyridines.By use of this approach aniline, C-1 anilines, and C-2 anilines, as well as lesse

Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation

Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.

Ethyl 2-Cyano-2-(2-nitrobenzenesulfonyloxyimino) Acetate (ortho-NosylOXY)-Mediated Double Beckmann Rearrangement of Ketoximes under Microwave Irradiation: A Mechanistic Perception

A method for Beckmann rearrangement using ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino) acetate (o-NosylOXY) under microwave irradiation is reported. Ketoximes (19 examples) are converted to the corresponding amides/lactams with 69–97% yields in ～10 minutes without any Lewis acid or co-catalyst. This is an example of halogen-free organocatalytic Beckmann rearrangement. Nuclear magnetic resonance (NMR)- and high-resolution mass spectrometry (HRMS)-based detailed mechanistic investigation suggest that o-NosylOXY acts as an initiator. Such initiators are reported before based on density functional theory (DFT) calculations. However, we report here the HRMS signatures of two transient intermediates, the nitrilium ion and the nitrilium ion's dimeric species. Rigorous NMR-based investigation of the reaction mechanism is performed. Our results indicate that the reported Beckmann rearrangement proceeds via two consecutive rearrangements. (Figure presented.).