366445-82-1

Basic information

• Product Name: 5-Bromo-6-methoxyisoquinoline
• Synonyms: 5-Bromo-6-methoxyisoquinoline
• CAS NO: 366445-82-1
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238
• Mol File: 366445-82-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Bromo-6-methoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-6-methoxyisoquinoline(366445-82-1)
• EPA Substance Registry System: 5-Bromo-6-methoxyisoquinoline(366445-82-1)

Safety Data

• Hazardous Substances Data: 366445-82-1(Hazardous Substances Data)

Upstream product

• 52986-70-6 6-methoxyisoquinoline 

Downstream Products

• 940890-88-0 5-bromo-6-methoxyisoquinoline-N-oxide hydrochloride 

Relevant articles and documents

2,4- DIARYL-SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases playsa role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors

ISOQUINOLINE DERIVATIVES

The invention relates to isoquinoline derivatives having the general Formula (I) wherein X is O, S or NH; Y is OH or NH2; m is 0, 1 or 2; n is 1 or 2; R1 is H, when Y is NH2; or R1 is H, (C1-4)alkyl or halogen, when Y is OH; R2 and R3 are independently H, (C1-4)alkyl or halogen; R is H or (C1-6)alkyl, optionally substituted with OH, (C1-4)- alkyloxy, (C1-4)alkyloxycarbonyl, (C3-7)cycloalkyl, which may optionally comprise a heteroatom selected from O and S, (C6-10)aryl, (C6-10)aryloxy or a 5- or 6-membered heteroaryl group comprising 1-3 heteroatoms independently selected from O, N and S, each aryl or heteroaryl group being optionally substituted with 1-3 substituents independently selected from (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkylsulfonyl and halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of the isoquinoline derivatives in the treatment of ROCK-I related disorders such as hypertension, atherosclerosis and glaucoma.

Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors

Screening of our in-house compound collection led to the discovery of 5-bromo-6-amino-2-isoquinoline 1 as a weak inhibitor of IMPDH. Subsequent optimization of 1 afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, represented by 17, with single-digit nanomolar potency against the enzyme.