367952-46-3

Basic information

• Product Name: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one
• Synonyms: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one
• CAS NO: 367952-46-3
• Molecular Weight: 361.671
• Mol File: 367952-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one(367952-46-3)
• EPA Substance Registry System: (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-chloromethyl-1,3-oxazolidin-5-one(367952-46-3)

Safety Data

• Hazardous Substances Data: 367952-46-3(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 50-00-0 formaldehyd 
• 150582-52-8 (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-1,3-oxazolidin-5-one 

Downstream Products

• 74163-81-8 L-Tic-OH 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 367952-49-6 (4S)-4-Benzyl-2,2-bis(trifluoromethyl)-3-methyl-1,3-oxazolidin-5-one 

Relevant articles and documents

Asymmetric pictet-spengler reactions: Synthesis of 1,2,3,4-tetrahydroisoquinoline carboxylic acid (Tic) chimeras

A preparatively simple diastereoselective synthesis of the amino acid chimera (1S,3S)-1,2,3,4-tetrahydroisoquinoline-1,3-dicarboxylic acid from hexafluoroacetone-protected phenylalanine and glyoxylic acid hydrate via Pictet-Spengler reaction is described. The potential of the reaction of hexafluoroacetone-protected phenylalanine with other aldehydes was scrutinized.