36839-55-1

Basic information

• Product Name: 1,2-BIS(2-IODOETHOXY)ETHANE
• Synonyms: ETHYLENE GLYCOL BIS(2-IODOETHYL) ETHER;1,2-BIS(2-IODOETHOXY)ETHANE;1,2-BIS(2-IODOETHOXY)ETHANE (STABILIZED WITH COPPER CHIP);1,2-BIS(2-IODOETHOXY)ETHANE, STABILIZED, 97%;1,8-Diiodo-3,6-dioxaoctane;1,2-Bis(2-iodoethoxy)ethane,97%,stabilized;1,2-Bis(ethylhexyl)ethane;1,2-Bis(2-iodoethoxy)ethane
• CAS NO: 36839-55-1
• Molecular Formula: C₆H₁₂I₂O₂
• Molecular Weight: 369.97
• Product Categories: Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 36839-55-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 293.5 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: Clear red-orange/Liquid
• Density: 2.028 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00301mmHg at 25°C
• Refractive Index: n20/D 1.572(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1,2-BIS(2-IODOETHOXY)ETHANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BIS(2-IODOETHOXY)ETHANE(36839-55-1)
• EPA Substance Registry System: 1,2-BIS(2-IODOETHOXY)ETHANE(36839-55-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 36839-55-1(Hazardous Substances Data)

Usage

Description

1,2-BIS(2-IODOETHOXY)ETHANE, also known as a crosslinking reagent, is a clear red-orange liquid that plays a crucial role in the synthesis of various materials. It is characterized by its ability to form strong bonds between different components, which makes it a valuable asset in the development of advanced materials with specific properties.

Uses

Used in Chemical Synthesis:
1,2-BIS(2-IODOETHOXY)ETHANE is used as a crosslinking reagent for the synthesis of various materials, including:
1. Zirconia-based, alkali-stable strong anion-exchange stationary phases: In this application, 1,2-BIS(2-IODOETHOXY)ETHANE is used to create robust and stable anion-exchange materials that can withstand alkaline conditions, making them suitable for various chemical and industrial processes.
2. Silica-coated nanoparticles: The crosslinking reagent is employed to enhance the stability and functionality of silica-coated nanoparticles, which can be utilized in various fields, such as drug delivery, catalysis, and environmental remediation.
3. Novel shell cross-linked (SCL) micelles: 1,2-BIS(2-IODOETHOXY)ETHANE is used to synthesize SCL micelles with pH-responsive poly(2-(diethylamino)ethyl methacrylate) cores and thermoresponsive poly(N-isopropylacrylamide) coronas. These micelles exhibit unique properties, such as pH and temperature sensitivity, which make them ideal candidates for targeted drug delivery and other advanced applications in the pharmaceutical and biotechnology industries.

InChI:InChI=1/C6H12I2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2

Upstream product

• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 7681-82-5 sodium iodide 

Downstream Products

• 93000-66-9 N,N'-bis(2-methoxybenzyl)-4,13-diaza-18-crown-6 
• 31249-95-3 Kryptofix 21 
• 23978-10-1 kryptofix 23 
• 312933-88-3 4'-{2-[2-(2-iodoethoxy)ethoxy]ethylthio}-5⁽⁴⁾,5'-bis(methylthio)-4⁽⁵⁾-[2-(4-nitrophenyl)ethylthio]tetrathiafulvalene 
• 1060978-46-2 1-{tris(4'-tert-butylbiphenyl-4-yl)methyl}-4-{2-[2-(2-iodoethoxy)ethoxy]ethoxy}benzene 
• 59559-06-7 1,8-diazido-3,6-dioxaoctane 
• 1309457-01-9 1-azido-2(2-(2-iodoethoxy) ethoxy) ethane 

Relevant articles and documents

A versatile strategy for the synthesis of crown ether-bearing heterocycles: Discovery of calcium-selective fluoroionophore

Heterocycles have been modified in various ways in the search for new functions, but few examples are known of crown ethers incorporating heterocycles in macro-ring systems. Here we report a simple and versatile synthesis of crown ether-bearing heterocycles. An acylurea moiety in the heterocycles is efficiently transformed to 'crown ether' of various ring sizes. The products included a Ca2+-selective fluoroionophore. Our simple methodology is expected to provide many novel functional heterocyclic compounds, including fluoroionophores and candidate pharmaceuticals.

Target protein degradation inducing compound, preparation method thereof and pharmaceutical composition for preventing or treating targeted protein related diseases containing the same as an active ingredient

The present invention relates to a degraducer for inducing the decomposition of target protein, a producing method thereof, and a pharmaceutical composition for preventing or treating target protein-related diseases by containing the degraducer as an active ingredient. A novel compound represented by chemical formula 1, ULB-L-PTM, by the present invention, as a degraducer compound inducing the decomposition of target protein using cereblon E3 ubiquitin ligase, is able to significantly achieve a target protein degradation-inducing activity with an excellent binding activity of a cereblon E3 ubiquitin ligase binder thereby, being able to achieve an excellent protein degradation activity by targeting protein or polypeptide related to various diseases. The bromodomain-containing pharmaceutical composition for preventing or treating protein-related diseases or conditions contains the novel compound represented by chemical formula 1 as an active ingredient and has a useful effect of providing a health functional food composition for prevention or improvement.(AA) Example 22 (nM, 24h)COPYRIGHT KIPO 2020

METHOD

The invention provides mitochondria-targeted chemiluminescent agents and their use in methods of photodynamic therapy (PDT). In particular, the invention provides compounds of general formula (I), and their pharmaceutically acceptable salts: (I) in which A represents a chemiluminescent moiety; each L, which may be the same or different, is either a direct bond or a linker; each B, which may be the same or different, represents a mitotropic moiety; n is an integer from 1 to 3, preferably 1; and x is an integer from 1 to 3, preferably 1. Such compounds find particular use in the treatment of deeply- sited tumours, e.g. glioblastoma multiforme (GBM), when used in combination with a photosensitizer or photosensitizer precursor.