3699-30-7

Basic information

• Product Name: potassium diethyldithiocarbamate
• Synonyms: Potassium diethyldithiocarbamate
• CAS NO: 3699-30-7
• Molecular Formula: C₅H₁₀NS₂*K
• Molecular Weight: 187.371
• EINECS: 223-031-3
• Mol File: 3699-30-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: potassium diethyldithiocarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: potassium diethyldithiocarbamate(3699-30-7)
• EPA Substance Registry System: potassium diethyldithiocarbamate(3699-30-7)

Safety Data

• Hazardous Substances Data: 3699-30-7(Hazardous Substances Data)

Usage

General Description

Potassium diethyldithiocarbamate is a chemical compound that is commonly used as a chelating agent in industrial applications. It is a white crystalline solid with the chemical formula K(S2CN(C2H5)2) and is often used in the extraction of metals such as copper, nickel, and cobalt from ores. The compound forms stable complexes with metal ions, making it useful in processes such as ore flotation and mineral separation. Additionally, potassium diethyldithiocarbamate has been studied for its potential use in the treatment of heavy metal poisoning, as it has been shown to effectively chelate toxic metals and facilitate their removal from the body. Despite its potential benefits, it is important to handle potassium diethyldithiocarbamate with caution, as it can be toxic if ingested or inhaled and can cause skin and eye irritation.

Upstream product

• 75-15-0 carbon disulfide 
• 109-89-7 diethylamine 

Downstream Products

• 51661-15-5 S-<(N-phenylcarbamoyl)methyl> diethyldithiocarbamate 
• 17258-83-2 N,N-di-ethyl-dithiocarbamic acid 3,5-di-tert-butyl-4-hydroxy-benzyl ester 
• 313053-72-4 Ni(C₆F₅)[P(C₆H₅)2CH₃][S₂CN(C₂H₅)2] 
• 97-77-8 disulfiram 
• 313053-74-6 Ni(C₆F₅)[P(C₂H₅)3][S₂CN(C₂H₅)2] 
• 313053-73-5 Ni(C₆F₅)[P(C₆H₅)(CH₃)2][S₂CN(C₂H₅)2] 
• 36472-83-0 bis(diethyldithiocarbamato)nitridorhenium(V) 
• 79873-74-8 bis(diethyldithiocarbamato)nitridotechnetium(V) 

Relevant articles and documents

Discovery and optimization of novel dual dithiocarbamates as potent anticancer agents

A series of dual dithiocarbamates were synthesized and evaluated for their in-vitro anticancer activities on human non-small cell lung cancer cell line H460. Nine compounds exhibited significant antiproliferative activities with IC50 less than 1 μM. Among them, compound 14m showed the highest inhibitory activity against H460 cell and inhibited the growth of nine types of tumor cells with IC50 values less than 1 μM. It also achieved IC50 of 54 nM and 23 nM against HepG2 and MCF-7 cell lines, respectively. Preliminary structure-activity relationship study indicated that: a) when the methyl group (region A) is substituted with benzene rings, ortho substitution on the benzene ring is favored for activity; b) substitution with heterocyclic structures at region A exhibited greater impact on the anti-tumor activity of compounds, in which pyridine ring, thiazole ring, coumarin and benzo[b]thiophene are favored and quinoline ring is the most favored; c) substitution with different amines (region B) also showed marked effect on the activity of compounds and dimethylamine and morpholine are preferred to other tested amines.

A manufacturing method of manufacturing method biscarbodithioate aq. amines and amine of the solid biscarbodithioate

PROBLEM TO BE SOLVED: To solve such a problem that the conventional method for obtaining a solid amine carbodithioate salt is not efficient, and in particular, when an amine carbodithioate salt has high solubility, it has been difficult to efficiently obtain the solid amine carbodithioate salt.SOLUTION: In a method for producing an amine carbodithioate salt by mixing an amine, carbon disulfide, and a metal hydroxide in an aqueous solution and making them react with one another, the solid amine carbodithioate salt is efficiently obtained by making 1.3 times equivalent or more of the metal hydroxide with respect to the amino group of the amine to react with carbon disulfide coexist therewith. Moreover, an aqueous solution of the amine carbodithioate salt with high concentration is simultaneously produced by further mixing the amine, carbon disulfide, and the metal hydroxide with the aqueous solution of the amine carbodithioate salt from which the solid amine carbodithioate salt has been separated and making them react with one another.

Synthesis and in vitro antifungal activity of some N,N-disubstituted dithiocarbamic acid esters derived from 2-methylquinazolinones

A series of 2-[(N,N-disubstituted thiocarbamoylthio)methyl]quinazolinones 9a-g; 10a; 10d; 11a-d and 12a were synthesized and evaluated for potential antifungal activity against a variety of fungal species. The synthesis of the target compounds was achieved by reaction of the potassium salts of disubstituted dithiocarbamic acids 8a-g and the respective 2-bromomethyl-4(3H)-quinazolinone 4 or 3-aryl-2- chloromethyl-4(3H)-quinazolinones 5-7. The dithiocarbamic acid derivatives were synthesized in a one step reaction from the appropriate amine, alcoholic potassium hydroxide solution and carbon disulfide. TLC and elemental analyses ascertained the purity of the synthesized compounds and their structures were confirmed by IR and 1H-NMR spectroscopy, 2-Methyl-4(3H)-quinazolinone 2, the precursor of the 2-bromomethyl intermediate 4, was selected as representative example for detailed spectroscopic investigations, including 300 MHz 1H- and 13CNMR in addition to HH COSY; APT and 1H13C HETCOR spectra, with the aim of establishing correct assignment of the spectral data of related compounds. The synthesized disubstituted dithiocarbamates 9a-g; 10a,d; 11a-d and 12a as well as tolnaftate and clotrimazole, as reference drugs, were tested in vitro at 2 and 5% concentrations against 23 pathogenic fungi. The study revealed that compound 9a exhibited broad spectrum inhibitory activity that is superior or comparable to that of the reference drugs against the tested fungal isolates. Selective fungistatic activity against Candida species was elicited by compound 9e and against Microsporum species as well as Trichophyton mentagrophytes was also observed for compound 9g. As a general pattern it might be postulated that some of the synthesized dithiocarbamate derivatives showed broad spectrum antifungal activity as compared with tolnaftate, the clinically used thiocarbamate compound, and also exhibited comparable activity to clotrimazole against Candida species and F. Solani.