370-77-4

Basic information

• Product Name: N-Benzyl-4-fluoroaniline Hydrochloride
• Synonyms: N-Benzyl-4-fluoroaniline Hydrochloride;Benzenemethanamine, N-(4-fluorophenyl)-;Benzyl-(4-fluoro-phenyl)-amine
• CAS NO: 370-77-4
• Molecular Formula: C₁₃H₁₂FN
• Molecular Weight: 237.7004232
• Product Categories: Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 370-77-4.mol
• Article Data: 161

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Benzyl-4-fluoroaniline Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-4-fluoroaniline Hydrochloride(370-77-4)
• EPA Substance Registry System: N-Benzyl-4-fluoroaniline Hydrochloride(370-77-4)

Safety Data

• Hazardous Substances Data: 370-77-4(Hazardous Substances Data)

Usage

Description

N-Benzyl-4-fluoroaniline Hydrochloride is a chemical compound that is identified as an impurity in Ezetimibe, a medication used to treat high cholesterol and reduce the absorption of cholesterol in the body. It is characterized by its chemical structure, which includes a benzyl group attached to a 4-fluoroaniline molecule and a hydrochloride ion.

Uses

Used in Pharmaceutical Industry:
N-Benzyl-4-fluoroaniline Hydrochloride is used as an impurity in the production of Ezetimibe (E975000) for its role in managing hyperlipidemia and inhibiting cholesterol absorption. The presence of this compound in Ezetimibe is significant for understanding the drug's overall composition and potential side effects.

Upstream product

• 331-98-6 N-benzylidene-4-fluoroaniline 
• 100-44-7 benzyl chloride 
• 371-40-4 4-fluoroaniline 
• 3526-69-0 N-<4-Rhodan-benzyliden>-4-fluor-anilin 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 83306-62-1 (E)-N-benzylidene-4-fluorobenzenamine 
• 100-39-0 benzyl bromide 
• 104-15-4 toluene-4-sulfonic acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 100-51-6 benzyl alcohol 
• 350-46-9 4-Fluoronitrobenzene 
• 100-42-5 styrene 

Downstream Products

• 119592-15-3 [3-[Benzyl-(4-fluoro-phenyl)-amino]-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester 
• 119591-97-8 [1-[Benzyl-(4-fluoro-phenyl)-amino]-2-(methoxycarbonyl-hydrazono)-propyl]-phosphonic acid diethyl ester 
• 75137-17-6 N-benzyl-4'-fluorobenzenesulfanilide 
• 143490-32-8 Benzyl-(4-fluoro-phenyl)-dithiocarbamic acid methyl ester 
• 83306-62-1 (E)-N-benzylidene-4-fluorobenzenamine 
• 839731-85-0 N-allyl-N-benzyl-4-fluoroaniline 
• 839731-89-4 2-allyl-N-benzyl-4-fluoroaniline 
• 143490-23-7 Benzyl-(4-fluoro-phenyl)-trifluoromethyl-amine 
• 119592-23-3 {3-[Benzyl-(4-fluoro-phenyl)-amino]-2-oxo-propyl}-phosphonic acid diethyl ester 
• 1422969-40-1 N¹,N⁴-dibenzyl-N¹,N⁴-bis(4-fluorophenyl)fumaramide 

Relevant articles and documents

Copper(i)-catalysed intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with phosphites

Intramolecular hydroarylation-redox cross-dehydrogenative coupling ofN-propargylanilines with phosphite diesters proceeded in the presence of Cu(i)-catalysts (20 mol%) to selectively give 2-phosphono-1,2,3,4-tetrahydroquinolines in good yields with 100% atomic utilization. P-H and two C-H bonds are activated at once and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.

Sulfated polyborate: A dual catalyst for the reductive amination of aldehydes and ketones by NaBH4

An efficient, quick, and environment-friendly one-pot reductive amination of aldehydes or ketones was developed. In ethanol at 70 °C, a imination catalyzed by sulfated polyborate and further reduced by sodium borohydride yields various amines. The present method has many significant benefits, including a shorter reaction time, excellent yields, and a hassle-free, straightforward experimental process. The reaction has a wide range of applications due to its flexibility, including secondary amine for reductive amination.

Photocatalytic one-pot multidirectional N-alkylation over Pt/D-TiO2/Ti3C2: Ti3C2-based short-range directional charge transmission

Visible-light-induced one-pot, multistep, and chemoselectivity adjustable reactions highlight the economical, sustainable, and green process. Herein, we report Pt nanoparticles dispersed on S and N co-doped titanium dioxide/titanium carbide (MXene) (3%Pt/