372-55-4

Basic information

• Product Name: 2,2-difluoroethyl ethyl ether
• Synonyms: 2,2-difluoroethyl ethyl ether
• CAS NO: 372-55-4
• Molecular Weight: 110.104
• Mol File: 372-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-difluoroethyl ethyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-difluoroethyl ethyl ether(372-55-4)
• EPA Substance Registry System: 2,2-difluoroethyl ethyl ether(372-55-4)

Safety Data

• Hazardous Substances Data: 372-55-4(Hazardous Substances Data)

Upstream product

• 3188-13-4 ethyl chloromethyl ether 
• 359-07-9 2-bromo-1,1-difluoroethane 

Downstream Products

• 381-73-7 Difluoroacetic acid 

Relevant articles and documents

The preparation of HCF2CdX and HCF2ZnX via direct insertion into the carbon halogen bond of CF2HY (Y = Br, I)

The difluoromethylcadmium and zinc reagents have been prepared in DMF via direct insertion of Cd0 into the carbon halogen bond of CF2HY (Y = Br, I). These reagents are stable at 65-75 °C and exhibit prolonged stability and activity at room temperature. Metathesis of the difluoromethylcadmium reagents with Cu(I)X (X = Br, Cl) at -55 °C rapidly produces difluoromethylcopper. The copper reagent is significantly less stable than the cadmium or zinc reagent and rapidly decomposes at room temperature. The difluoromethylcadmium and copper reagents exhibit good reactivity with allylic halides, propargylic derivatives and 1-iodoalkynes to provide good yields of the corresponding difluoromethylalkenes, difluoromethylallenes and difluoromethyl-2-alkynes. Alkylation is successful only with reactive alkyl halides. Generally, the difluoromethylcopper reagent is more reactive than the difluoromethylcadmium reagent and generally exhibits higher regioselectivity in reactions that can occur by either α- or γ-attack.