37386-15-5

Basic information

• Product Name: PYRROLIDIN-1-YL-ACETIC ACID
• Synonyms: AKOS BBS-00000323;AKOS BC-0363;1-PYRROLIDINEACETIC ACID;1-PYRROLIDINYLACETIC ACID;N-PYRROLIDINOACETIC ACID;SALOR-INT L481092-1EA;PYRROLIDIN-1-YL-ACETIC ACID;RARECHEM AL BO 0350
• CAS NO: 37386-15-5
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.16
• Mol File: 37386-15-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 184-185 °C
• Boiling Point: 233.8 oC at 760mmHg
• Flash Point: 95.2 oC
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly, Sonicated, Heated), Methanol (Slightly)
• PKA: 2.47±0.10(Predicted)
• CAS DataBase Reference: PYRROLIDIN-1-YL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PYRROLIDIN-1-YL-ACETIC ACID(37386-15-5)
• EPA Substance Registry System: PYRROLIDIN-1-YL-ACETIC ACID(37386-15-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 37386-15-5(Hazardous Substances Data)

Usage

Description

PYRROLIDIN-1-YL-ACETIC ACID, also known as 1-Pyrrolidineacetic Acid, is an organic compound with the chemical structure featuring a pyrrolidine ring and an acetic acid group. It is a versatile molecule that serves as a key intermediate in the synthesis of various pharmaceuticals and other chemical products. Its unique structure allows it to participate in a wide range of organic reactions, making it a valuable compound in the field of chemistry.

Uses

Used in Pharmaceutical Industry:
PYRROLIDIN-1-YL-ACETIC ACID is used as a reactant and reagent for the synthesis of various pharmaceutical compounds. Its ability to participate in different organic reactions makes it a crucial component in the development of new drugs and medications.
Used in Cosmetic Industry:
PYRROLIDIN-1-YL-ACETIC ACID is used as an active ingredient in cosmetic products, particularly those aimed at preventing or ameliorating wrinkles. Its incorporation into these products helps to improve skin elasticity and reduce the appearance of fine lines and wrinkles, providing anti-aging benefits to users.

InChI:InChI=1/C6H11NO2/c8-6(9)5-7-3-1-2-4-7/h1-5H2,(H,8,9)

Upstream product

• 53342-21-5 pyrrolidin-1-yl acetic acid benzyl ester 
• 22041-18-5 methyl 2-(pyrrolidin-1-yl)acetate 
• 123-75-1 pyrrolidine 
• 79-08-3 bromoacetic acid 
• 22041-19-6 ethyl 2-(pyrrolidin-1-yl) acetate 

Downstream Products

• 1616289-79-2 C₃₄H₄₁ClN₄O₄ 
• 1541185-01-6 5-[4-(2H-pyrazol-3-yl)phenoxy]-2-pyrrolidin-1-ylmethyl-1H-benzoimidazole 
• 1541189-15-4 C₂₇H₃₇N₅O₃Si 
• 1460305-87-6 benzyl N-[(12R,16S,18S)-8,13-dioxo-16-{[2-(1-pyrrolidinyl)acetyl]amino}-20-oxa-9,14-diazatetracyclo[19.3.1.0²'⁷.0¹⁴'¹⁸]pentacosa-1⁽²⁵⁾,2,4,6,21,23-hexaen-12-yl]carbamate 
• 1214893-94-3 N-phenyl-5-(2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazol-6-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine 
• 842120-82-5 dibenzyl pyrrolidinoglycyl-L-prolyl-L-glutamate 

Relevant articles and documents

Nitrogen-containing cyclic compounds as iminium ion sources for selected reaction monitoring detection of derivatized analytes

Liquid chromatography–tandem mass spectrometry is one of the most sensitive tools for determination of trace amounts of analytes in metabolomics and proteomics. The highest sensitivity is achieved in selected reaction monitoring detection, which involves fragmentation of the molecular ion between two levels of mass selection. However, fragmentation of some compounds is complicated. Detection sensitivity of such analytes may be increased by derivatizing them with a specific moiety fragmentation of which results in product ion of high abundance. In this work, we reveal the influence of iminium ions' structures on their stability by comparing six nitrogen-containing cyclic compounds as derivatization reagents for tandem mass spectrometric analysis of amino group-containing analyte. Commercially available starting materials (piperidine, 2,6-dimethylpiperidine, 1-methylpiperazine, morpholine, pyrrolidine and 1-cyanomethyl-3-methylimidazolium ionic liquid) were used for the synthesis of corresponding carboxylic acids which were further used for derivatization of the model analyte tryptamine. Liquid chromatographic–mass spectrometric analysis of differently derivatized tryptamine was performed for the evaluation of release and stability of corresponding iminium ions under collision-induced dissociation conditions. As a result, morpholine moiety was shown being the most promising iminium ion source among tested compounds. Possible sub-fragmentation pathways of investigated iminium ions were discussed, and the structures of secondary product ions were proposed.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

TIGECYCLINE AND METHODS OF PREPARATION

Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.