374-01-6

Basic information

• Product Name: 1,1,1-TRIFLUORO-2-PROPANOL
• Synonyms: 1,1,1-trifluoro-2-propano;1-Methyl-2,2,2-trifluoroethanol;2-Propanol, 1,1,1-trifluoro-;2-propanol,1,1,1-trifluoro-;1,1,1-TRIFLUORO-2-PROPANOL;1,1,1-TRIFLUOROPROPAN-2-OL;1,1,1-TRIFLUOROPROPANOL-2;1,1,1-TRIFLUOROISOPROPANOL
• CAS NO: 374-01-6
• Molecular Formula: C₃H₅F₃O
• Molecular Weight: 114.07
• EINECS: 206-773-2
• Product Categories: Alcohols;C2 to C6;Oxygen Compounds
• Mol File: 374-01-6.mol
• Article Data: 35

Chemical Properties

• Melting Point: -52 °C
• Boiling Point: 81-82 °C(lit.)
• Flash Point: 65 °F
• Appearance: /
• Density: 1.259 g/mL at 25 °C(lit.)
• Vapor Pressure: 109mmHg at 25°C
• Refractive Index: n20/D 1.316(lit.)
• PKA: 12.53±0.20(Predicted)
• Water Solubility: Fully miscible in water.
• BRN: 1734738
• CAS DataBase Reference: 1,1,1-TRIFLUORO-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUORO-2-PROPANOL(374-01-6)
• EPA Substance Registry System: 1,1,1-TRIFLUORO-2-PROPANOL(374-01-6)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-33-36
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• TSCA: T
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 374-01-6(Hazardous Substances Data)

Usage

Description

1,1,1-Trifluoro-2-propanol, a fluoroalcohol, is an organic solvent characterized by its clear colorless liquid appearance. It has been subjected to vibrational spectral analysis of its OH and OD groups, providing insights into its chemical properties.

Uses

1. Used as a Chemical Building Block:
1,1,1-Trifluoro-2-propanol is utilized as a chemical building block in various chemical reactions and processes due to its unique properties as a fluoroalcohol.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,1,1-trifluoro-2-propanol is used as a solvent for the synthesis of various drugs and active pharmaceutical ingredients. Its unique properties as a fluoroalcohol make it a valuable component in the development of new medications.
3. Used in Chemical Synthesis:
1,1,1-Trifluoro-2-propanol is employed as a solvent in chemical synthesis, particularly in the production of fluorinated compounds. Its ability to dissolve a wide range of substances and its compatibility with various reaction conditions make it a versatile choice for chemical synthesis processes.
4. Used in Research and Development:
Due to its unique properties, 1,1,1-trifluoro-2-propanol is also used in research and development for studying the effects of fluorination on various chemical reactions and exploring new applications in different fields, including materials science and pharmaceuticals.

InChI:InChI=1/C3H5F3O/c1-2(7)3(4,5)6/h2,7H,1H3/t2-/m0/s1

Upstream product

• 359-41-1 1,1,1-trifluoro-2,3-epoxypropane 
• 917-64-6 methyl magnesium iodide 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 917-54-4 methyllithium 
• 344324-54-5 trifluoroisopropyl fluorosulfite 
• 677-21-4 1,1,1-trifluoropropylene 
• 130025-34-2 (S)-2-trifluoromethyl-oxirane 
• 88378-50-1 (S)-(+)-1-Bromo-3,3,3-trifluoro-2-propanol 
• 18454-30-3 (+)-3-(1-trifluoromethylethoxy)propionic acid 
• 143142-90-9 (2R)-2-(trifluoromethyl)oxirane 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 67-56-1 methanol 

Downstream Products

• 400-37-3 acetic acid-(β,β,β-trifluoro-isopropyl ester) 
• 845616-82-2 5-methane-sulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid 
• 1246442-51-2 carbonic acid 4-nitro-phenyl ester (S)-2,2,2-trifluoro-1-methyl-ethyl ester 
• 1426408-85-6 1-chloro-3-((R)-2,2,2-trifluoro-1-methylethoxymethyl)benzene 
• 1426408-92-5 4,4,5,5-tetramethyl-2-[3-((R)-2,2,2-trifluoro-1-methylethoxymethyl)phenyl]-[1,3,2]dioxaborolane 
• 374-01-6 (S)-1,1,1-trifluoro-2-propanol 
• 99366-91-3 2-chloro-4-nitro-1-((1,1,1-trifluoropropan-2-yl)oxy)benzene 
• 32793-56-9 1,1,1-trifluoro-2-difluoromethoxypropane 
• 421-50-1 1,1,1-trifluoro-2-propanone 

Relevant articles and documents

-

-

-

-

ION CHANNEL MODULATORS

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Method for oxidative cracking of compound containing unsaturated double bonds

The invention relates to a method for oxidative cracking of a compound containing unsaturated double bonds. The method comprises the following steps: (A) providing a compound (I) containing unsaturated double bonds, a trifluoromethyl-containing reagent and a catalyst, wherein the catalyst is shown as a formula (II): M(O)mL1yL2z (II), M, L1, L2, m, y, z, R1, R2 and R3 being defined in the specification; and (B) mixing the compound containing the unsaturated double bonds and the trifluoromethyl-containing reagent, and performing an oxidative cracking reaction on the compound containing the unsaturated double bonds in the presence of air or oxygen by using the catalyst to obtain a compound represented by formula (III),.

ION CHANNEL MODULATORS

Provided, in part, are compounds of Formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.