374067-85-3

Basic information

• Product Name: 4-[[4-[(4-BROMO-2,6-DIMETHYLPHENYL)AMINO]-2-PYRIDIDINYL]AMINO]-BENZONITRILE
• Synonyms: 4-[[4-[(4-BROMO-2,6-DIMETHYLPHENYL)AMINO]-2-PYRIDIDINYL]AMINO]-BENZONITRILE;Despropenenitrile BroMo Rilpivirine;4-[[4-[(4-BroMo-2,6-diMethylphenyl)aMino]-2-pyriMidinyl]aMino]-benzonitrile;Despropenenitrile Bromo Rilpivirin
• CAS NO: 374067-85-3
• Molecular Formula: C₁₉H₁₆BrN₅
• Molecular Weight: 394.27
• Product Categories: Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 374067-85-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 578.3°Cat760mmHg
• Flash Point: 303.5°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 2.27E-13mmHg at 25°C
• Refractive Index: 1.684
• Storage Temp.: -20°C Freezer
• Solubility: Acetonitrile (Very Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-[[4-[(4-BROMO-2,6-DIMETHYLPHENYL)AMINO]-2-PYRIDIDINYL]AMINO]-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[4-[(4-BROMO-2,6-DIMETHYLPHENYL)AMINO]-2-PYRIDIDINYL]AMINO]-BENZONITRILE(374067-85-3)
• EPA Substance Registry System: 4-[[4-[(4-BROMO-2,6-DIMETHYLPHENYL)AMINO]-2-PYRIDIDINYL]AMINO]-BENZONITRILE(374067-85-3)

Safety Data

• Hazardous Substances Data: 374067-85-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Rilpivirine (R509800) derivative.

InChI:InChI=1/C19H16BrN5/c1-12-9-15(20)10-13(2)18(12)24-17-7-8-22-19(25-17)23-16-5-3-14(11-21)4-6-16/h3-10H,1-2H3,(H2,22,23,24,25)

Upstream product

• 873-74-5 4-Aminobenzonitrile 
• 24596-19-8 4-bromo-2,6-dimethylphenylamine 
• 244768-32-9 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile 

Downstream Products

• 500287-78-5 4-{4-[4-(5-formylfuran-2-yl)-2,6-dimethylphenylamino]pyrimidin-2-ylamino}benzonitrile 
• 500288-00-6 4-{4-[4-((E)-2-Cyano-1-methyl-vinyl)-2,6-dimethyl-phenylamino]-pyrimidin-2-ylamino}-benzonitrile 
• 500287-72-9 rilpivirine 
• 500288-66-4 (E)- 3-{4-[2-(4-(cyanophenylamino)-1-oxo-pyrimidin-4-yl)amino]-3,5-dimethylphenyl}acrylamide 
• 500288-49-3 C₂₃H₁₉N₅S 
• 500287-74-1 C₂₇H₂₁N₅O 
• 500287-76-3 C₂₃H₁₉N₅O 
• 500288-70-0 4-((4-((3,5-dimethyl-(1,1'-biphenyl)-4-yl)amino)pyrimidin-2-yl)amino)benzonitrile 
• 500288-88-0 4-((4-((4'-chloro-3,5-dimethyl-(1,1'-biphenyl)-4-yl)amino)pyrimidin-2-yl)amino)benzonitrile 
• 500288-79-9 4-((4-((3'-chloro-3,5-dimethyl-(1,1'-biphenyl)-4-yl)amino)pyrimidin-2-yl)amino)benzonitrile 
• 500288-84-6 4-((4-((3,3',5-trimethyl-(1,1'-biphenyl)-4-yl)amino)pyrimidin-2-yl)amino)benzonitrile 

Relevant articles and documents

Method for preparing high-purity ribavirin intermediate by one-pot method (by machine translation)

The invention relates to the technical field of chemical medicine, in particular to a method for preparing a high-purity ribavirin intermediate by a one-pot method. The method comprises the following steps: (1) replacing the compound I with the compound II to obtain the reaction liquid of the compound III. (2) Acrylamide was added to III reaction liquid of the compound, and the reaction liquid of compound IV was obtained under Heck reaction conditions. (3) In the reaction solution of Compound IV, activated carbon is first added for decolorization treatment, and then a poor solvent is added for crystallization to obtain a white compound IV, i.e. a ripe intermediate. The method for preparing the high-purity ribavirin intermediate by one-pot method is scientific, reasonable, simple and feasible, improves product purity and yield, and is suitable for large-scale production. (by machine translation)

Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid

The invention provides a novel pharmaceutical composition comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base characterized in that the acid respectively base:drug compound ratio is at least 1:1 by weight.

PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE

Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).